Hymenidin is an antagonist of serotonergic receptors and has antiprotozoal activity. Additionally, hymenidin inhibits Cdk5/p35 (IC50 = 4 μM) and GSK-3β (IC50 = 12 μM).
1. Kobayashi, J., et al., 1986. A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp. Experientia. 42(10): 1176-7. PMID: 3770140 2. Meijer, L., et al., 2000. Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. Chemistry & biology. 7(1): 51-63. PMID: 10662688 3. Bickmeyer, Ulf., et al., 2004. Brominated pyrrole alkaloids from marine Agelas sponges reduce depolarization-induced cellular calcium elevation. Toxicon : official journal of the International Society on Toxinology. 44(1): 45-51. PMID: 15225561
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