Heterotrimeric G Protein para análisis funcionales de las repuestas celulares a Heterotrimeric G Protein
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Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors. Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (e.g., adenylyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein α, β and γ polypeptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their a subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Evidence, however, has established an important regulatory role for the βγ subunits. The Gs subfamily of Gα subunits includes two closely related proteins, Gα s and Gα olf, which respectively stimulate adenylyl cyclase and mediate response to olfactory stimuli.
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