Molecular structure of Galeterone, CAS Number: 851983-85-2
Galeterone (CAS 851983-85-2)
See product citations (1)
Alternate Names:
TOK-001
Application:
Galeterone is an antagonist to LNCaP AR
CAS Number:
851983-85-2
Purity:
≥98%
Molecular Weight:
388.55
Molecular Formula:
C26H32N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Galeterone is effective at preventing binding of [3H]-R1881 to the mutant LNCaP AR (T877A) and to T575A mutant AR in PC3 cells with IC50 values of 845 nM and 454 nM, respectively. The effects on AR significantly reduce cellular phospho-4EBP1 levels. Galeterone potently inhibits the proliferation of LNCaP and LAPC4 cells in the with IC50 values of 2.6 μM and 4 μM, respectively. Galeterone induces the endoplasmic reticulum s.tress response resulting in down-regulation of cyclin D1 protein expression and cyclin E2 mRNA in vitro. Galeterone is a selective CYP17 inhibitor and AR (androgen receptor) antagonist
Galeterone (CAS 851983-85-2) References
1. Handratta VD, et al. J Med Chem, 2005, 48(8), 2972-2984. 2. Vasaitis T, et al. Mol Cancer Ther, 2008, 7(8), 2348-2357. 3. Bruno RD, et al. Mol Cancer Ther, 2008, 7(9), 2828-2836. 4. Schayowitz A, et al. Mol Cancer Ther, 2008, 7(1), 121-132. 5. SchayowiInhibitor of:
Androgen Receptor, AR, ARL13B, ARL3, C4BPαZ, CYP, CYP17A1, MSE55, Prostate Tumor Marker, PSA, and SPANX-N3.Activator of:
Abp1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Galeterone, 5 mg | sc-364495 | 5 mg | $191.00 | |||
Galeterone, 25 mg | sc-364495A | 25 mg | $572.00 |