FM19G11An inhibitor of Hypoxia Inducible Factors α (HIFα)

FM19G11 (CAS 329932-55-0)

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Sinónimo: HIF-1α/2α Inhibitor IV; HIF Inhibitor IV; 2-Oxo-2-((p-tolyl)ethyl)-3-((2,4-dinitro)benzamido)-benzoate
Solicitud: An inhibitor of Hypoxia Inducible Factors α (HIFα)
Número de CAS: 329932-55-0
Peso Molecular: 463.40
Fórmula Molecular: C23H17N3O8
* Refer to Certificate of Analysis for lot specific data (including water content).

FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), which are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models.


References

PMID: 19897487

Estado de Materia :
Solid
Solubilidad :
Soluble in DMSO (≥ 40 mg/ml).
ALMACENAMIENTO :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Alemania :
3
PubChem CID :
1730746
Número MDL :
MFCD01174289
SMILES :
CC1=CC=C(C=C1)C(=O)COC(=O)C2=CC(=CC=C2)NC(=O)C3=C(C=C(C=C3)[N+](=O)[O-])[N+](=O)[O-]

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CERTIFICADO DE ANÁLISIS

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FM19G11  Menciones del Producto

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Citaciones 1 a 1 de un total de 1

PMID: # 28232488  Yang, X. et al. 2017. J. Biol. Chem. 292: 5981-5991.

Citaciones 1 a 1 de un total de 1
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