E2F-2 Antibody (CC11): sc-56663

E2F-2 Antibody (CC11) is a mouse monoclonal IgG2a antibody that detects E2F-2 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). E2F-2 plays a crucial role in the regulation of the cell cycle, particularly in the transition from the G1 phase to the S phase, where DNA synthesis occurs. This regulation is vital for proper cell proliferation and differentiation, as dysregulation can lead to uncontrolled cell growth and contribute to cancer development. E2F-2 is part of a larger family of E2F transcription factors, which interact with the retinoblastoma protein (Rb) to form a transcriptional regulatory complex that governs the expression of genes essential for cell cycle progression. The ability of E2F-2 to form heterodimers with the DP-1 protein enhances transcriptional activity, allowing for precise control over the genes involved in cell cycle regulation. Understanding the function of E2F-2 and its interactions is important for elucidating the mechanisms of cell cycle control and the potential implications in oncogenesis, making anti-E2F-2 antibody (CC11) a valuable tool for researchers studying these critical biological processes.

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E2F-2 Antibody (CC11) References:

1. E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts.  |  Swartz, KL., et al. 2017. Mol Cell Biol. 37: PMID: 27795297
2. E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment.  |  González-Romero, F., et al. 2021. Cancer Res. 81: 2874-2887. PMID: 33771899
3. E2F2 stimulates CCR4 expression and activates synovial fibroblast-like cells in rheumatoid arthritis.  |  Xu, W., et al. 2021. Cent Eur J Immunol. 46: 27-37. PMID: 33897281
4. E2F2 inhibition induces autophagy via the PI3K/Akt/mTOR pathway in gastric cancer.  |  Li, H., et al. 2021. Aging (Albany NY). 13: 13626-13643. PMID: 34091441
5. Expression and Prognostic Role of E2F2 in Hepatocellular Carcinoma.  |  Shen, S. and Wang, Y. 2021. Int J Gen Med. 14: 8463-8472. PMID: 34824545
6. Alteration of E2F2 Expression in Governing Endothelial Cell Senescence.  |  Liu, H., et al. 2022. Genes (Basel). 13: PMID: 36140689
7. Shentao Ruangan formula promotes apoptosis via the E2F2-p53 pathway in hepatocellular carcinoma.  |  Zeng, Z., et al. 2023. Phytomedicine. 109: 154565. PMID: 36610125
8. E2F2 is upregulated by the ERK pathway and regulates decidualization via MCM4.  |  Zheng, W., et al. 2023. Gene. 871: 147400. PMID: 37028609
9. E2F2 modulates cell adhesion through the transcriptional regulation of PECAM1 in multiple myeloma.  |  Chen, SN., et al. 2023. Br J Haematol. 202: 840-855. PMID: 37365680
10. E2F2 Reprograms Macrophage Function By Modulating Material and Energy Metabolism in the Progression of Metabolic Dysfunction-Associated Steatohepatitis.  |  Liu, Z., et al. 2024. Adv Sci (Weinh). 11: e2410880. PMID: 39465673

The preferred E2F-2 antibody is E2F-2 Antibody (TFE-25): sc-9967.