CNDP2 Antibody (AT15E5): sc-517394

CNDP2 Antibody (AT15E5) is a mouse monoclonal IgG1 kappa light chain antibody that detects CNDP2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-CNDP2 antibody (AT15E5) is available as a non-conjugated format. CNDP2 is a cytosolic, non-specific dipeptidase that belongs to the peptidase M20A family, playing a crucial role in various physiological processes by regulating peptide metabolism. CNDP2 is expressed across all adult and fetal tissues, with a specific isoform lacking exons 3 and 4 being present in all fetal tissues but only in adult liver. In human hepatocellular carcinoma (HCC), this isoform, also known as carboxypeptidase of glutamate-like B (CPGL-B), is frequently underexpressed, which has been linked to significant clinical implications, including a correlation with HCC venous invasion and tumor microsatellite formations. CPGL-B overexpression in HCC cells has been shown to markedly inhibit cell viability, colony formation, invasiveness, and tumor formation, highlighting its potential as a therapeutic target and a biomarker for HCC progression.

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CNDP2 Antibody (AT15E5) References:

1. Identification of carboxypeptidase of glutamate like-B as a candidate suppressor in cell growth and metastasis in human hepatocellular carcinoma.  |  Zhang, P., et al. 2006. Clin Cancer Res. 12: 6617-25. PMID: 17121880
2. Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies.  |  Wanic, K., et al. 2008. Diabetes. 57: 2547-51. PMID: 18753673
3. Colocalization of a carnosine-splitting enzyme, tissue carnosinase (CN2)/cytosolic non-specific dipeptidase 2 (CNDP2), with histidine decarboxylase in the tuberomammillary nucleus of the hypothalamus.  |  Otani, H., et al. 2008. Neurosci Lett. 445: 166-9. PMID: 18790006
4. [A child with a ring 18 chromosome : 46,XX,r(18) and a decreased enzymatic activity of erythrocyte peptidase A (author's transl)].  |  Serville, F., et al. 1979. Ann Pediatr (Paris). 26: 711-5. PMID: 555611
5. The evidential value of peptidase A as a semen typing system.  |  Parkin, BH. 1981. J Forensic Sci. 26: 398-404. PMID: 6114980

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CNDP2 Antibody (AT15E5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-CNDP2 Antibody (AT15E5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CNDP2 Antibody (AT15E5) Specifications

Alternate Product Name: CNDP2

Product Clone Name: AT15E5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-475

Epitope Target: CNDP2

Epitope Species: human

Product Reactivity/Detection: CNDP2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and < 1% glycerol

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CNDP2 Antibody (AT15E5): N/A