Anti-CD45 Anticuerpo 35-Z6 es un monoclonal de ratón IgG1 κ CD45 Anticuerpo, ver las 71 publicaciones, proporcionado como 200 µg/ml
raised against the extracellular domain of CD45 of human origin
CD45 Anticuerpo (35-Z6) es recomendado para detectar CD45 de mouse, rat y human origen, mediante WB, IP, IF, IHC(P) y FCM
CD45 Anticuerpo (35-Z6) es disponible conjugado a agarosa para IP; HRP para WB, IHC(P) y ELISA; y tanto a phycoerythrin como a FITC para IF, IHC(P) y FCM
también disponible conjugado a Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 o Alexa Fluor® 647 para WB (RGB), IF, IHC (P) y FCM
también disponible conjugado a Alexa Fluor® 680 o Alexa Fluor® 790 para WB (NIR), IF y FCM
también disponibles conjugados a Alexa Fluor® 405 para IF, IHC(P) y FCM
Contacte con nosotros para recibir GRATIS 10 µg de muestra de CD45 (35-Z6): sc-1178.
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CD45 Antibody (35-Z6) for WB and IHC(P) applications. These reagents are now offered in bundles with CD45 Antibody (35-Z6) (see ordering information below).
CD45 para análisis funcionales de las repuestas celulares a CD45
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CD45 Antibody (35-Z6) is a high quality monoclonal CD45 antibody (also designated PTPRC antibody or protein tyrosine phosphatase receptor type C antibody) suitable for the detection of the CD45 protein of mouse, rat and human origin. CD45 Antibody (35-Z6) is available as both the non-conjugated anti-CD45 antibody form, as well as multiple conjugated forms of anti-CD45 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. CD45 has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45 are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5 and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45, while the intracellular domain is conserved. CD45 functions as a phosphotyrosine phosphatase, a vital component for efficient tyrosine phosphorylation induction by the TCR/CD3 complex. The tyrosine phosphatase activity of CD45 is contained within the conserved intracellular domain. Src and Syk family protein tyrosine kinases are utilized by the TCR/CD3 complex to initiate signaling cascades. Several members of these two families, including Lck, Fyn and ZAP-70, have been implicated as physiological substrates of CD45.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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