AS 1892802 CAS: 928320-12-1
MF: C20H19N3O2
MW: 333.38
An ATP-competitive ROCK inhibitor.

AS 1892802 (CAS 928320-12-1)

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Nombres Alternativos: AS1892802; AS-1892802
Solicitud: AS 1892802 is an ATP-competitive ROCK inhibitor
Número de CAS: 928320-12-1
Peso Molecular: 333.38
Fórmula Molecular: C20H19N3O2
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).
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AS 1892802 is a potent, ATP-competitive ROCK inhibitor with IC50 values of 52, 57 and 122 nM for human ROCK2, rat ROCK2 and human ROCK1, respectively. In rat models, AS 1892802 has been shown to prevent the formation of tibial cartilage lesions due to MIA induction of osteoarthritis.


References

R. Li et al. Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors. J. Med. Chem. 2012, 55, 2474−2478.

N. Takeshita et al. Alleviating Effects of AS1892802, a Rho Kinase Inhibitor, on Osteoarthritic Disorders in Rodents. J. Pharmacol. Sci. 2011, 115, 481–489.

E. Yoshimi et al. Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis. J. Pharmacol. Exp. Ther. 2010, 334, 955-963.

E. Yoshimi et al. Sustained analgesic effect of the Rho kinase inhibitor AS1892802 in rat models of chronic pain. J. Pharmacol. Sci. 2010, 114, 119-122.

Estado de Materia :
Solid
Solubilidad :
Soluble in DMSO (100 mM), and ethanol (25 mM).
ALMACENAMIENTO :
Store at 4° C
Punto de ebullición :
~531.2° C at 760 mmHg (Predicted)
Densidad :
~1.3 g/cm3 (Predicted)
Indice de Refracción :
n20D 1.66 (Predicted)
Actividad Óptica :
α20/D +85.8°, c = 0.68 in methanol
IC50 :
ROCK2: IC50 = 52 nM (human); ROCK2: IC50 = 57 nM (rat); ROCK1: IC50 = 122 nM (human)
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
PubChem CID :
SMILES :
C1=CC=C(C=C1)[[email protected]@H](CO)NC(=O)NC2=CC=C(C=C2)C3=CC=NC=C3

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CERTIFICADO DE ANÁLISIS

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