5-Azacytidine is a potent growth inhibitor and a cytotoxic agent. 5-Azacytidine acts as a demethylating agent by inhibiting DNA methyltransferase (Dnmt), forming covalent adducts with cellular DNMT1 depleting enzyme activity. 5-Azacytidine also improves the efficiency of reprogramming of stem cells and induces differentiation of mesenchymal stem cells into cardiomyocytes.
Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)
Estado de Materia
Soluble in water (50 mg/ml), DMSO (49 mg/ml at 25° C), ethanol (~30 mg/ml), methanol, and DMF (~30 mg/ml).
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