S-PMH MF: C12H12N2O2S
MW: 248.30

S-PMH

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 120ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Molekulargewicht: 248.30
Summenformel: C12H12N2O2S
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
* Schauen Sie auf das Analysezertifikat (CoA), um die genauen Daten (inkl. Wassergehalt) Ihrer Produktionscharge (Lot) zu sehen.
loading

This augments cell-cell adhesion by enhancing tight and adherens junctions and by abolishing the destabilizing actions of Calcitonin (CT) on these complexes. Calcitonin and its receptor are expressed in prostate cell cancers and play a pivotal role in metastasis and tumorgenesis. CT has been shown to promote prostate cancer metastasis by reducing cell-cell adhesion through the disassembly of tight and adherens junctions and activation of B-catenin signaling. PMH can blocks CT-stimulated alphavbeta3 activity (a key factor in bone metastasis). In a nude mice model I.p. administered PMH and its S-ethyl derivative decreased orthotopic tumor growth and inhibited the formation of tumor micrometastases in distant organs. PMH is relatively nontoxic in a cell proliferation assay.


Literaturhinweise

1. Shah, G.V., et al. 2009. Mol. Cancer Ther. 8: 509-520. PMID: 19276166
2. Mudit, M., et al. 2009. Bioorg. Med. Chem. 17: 1731-1738. PMID: 19195897

Erscheinung :
Powder
Aggregatzustand :
Solid
Löslichkeit :
DMSO: >20 mg/mL
LAGERUNG: :
Store at 4° C
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
PubChem CID :
SMILES :
CCSC1=CC=C(C=C1)/C=C\2/C(=O)NC(=O)N2

SDS (MSDS) herunterladen

Analysenzertifikat

Um PDF-Dokumente zu Drucken oder zu Bearbeiten
benötigen Sie Adobe Acrobat Reader

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 109ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 8ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;