(S)-(−)-Blebbistatin CAS: 856925-71-8
MF: C18H16N2O2
MW: 292.34
An inhibitor of myosin II.

(S)-(−)-Blebbistatin (CAS 856925-71-8)

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(S)-(−)-Blebbistatin is rated 5.0 out of 5 by 2.
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Alternative Namen: 1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2.3-b]-7-methylquinolin-4-one; (−)-Blebbistatin
Anwendungen (S)-(−)-Blebbistatin is an inhibitor of myosin II
CAS Nummer: 856925-71-8
Reinheit: ≥98%
Molekulargewicht: 292.34
Summenformel: C18H16N2O2
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
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(S)-(−)-Blebbistatin is a selective inhibitor of myosin II (MYH2). It also inhibits contraction of the cleavage furrow without disrupting of mitosis or the contractile ring assembly. (S)-(−)-Blebbistatin exhibits rapid and reversible blocking of cell blebbing, as well as disruption of directed cell migration and of cytokinesis in vertebrate cells.


Literaturhinweise

1. Straight, A.F., et al. 2003. Science. 299: 1743-1747. PMID: 12637748
2. Limouze, J., et al. 2004. J. Mus. Res. Cell Motil. 25: 337-41. PMID: 15548862

Aggregatzustand :
Solid
Löslichkeit :
Soluble in methanol (1.5 mg/ml), DMSO (100 mM), Dichloromethane, ethyl acetate, chloroform, methylene chloride, DMF (~12.5 mg/ml), 1:1 solution of DMF:PBS (pH 7.2) (~0.5 mg/ml), and water (0.5 mg/ml at 25° C).
LAGERUNG: :
Desiccate at -20° C
Schmelztemperatur :
>205° C (dec.)
Sidepunkt :
~507.3° C at 760 mmHg (Predicted)
Dichte :
~1.3 g/cm3 (Predicted)
Brechungsindex :
n20D 1.68 (Predicted)
Optische Aktivität :
α20/D -103°, c = 1.21 in chloroform
IC50 :
myosin II ATPase activity: IC50 = ~0.5 - 5 µM; ATPase: IC50 = ~2 µM; smooth muscle myosin: IC50 = 80 µM
pK Werte :
pKa: 11.5 (Predicted), pKb: 4.62 (Predicted)
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
Deutsche WGK :
3
PubChem CID :
MDL-Nummer :
MFCD08460907
SMILES :
CC1=CC2=C(C=C1)N=C3[[email protected]](C2=O)(CCN3C4=CC=CC=C4)O

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Analysenzertifikat

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