(S)-(−)-Blebbistatin is a selective inhibitor of myosin II (MYH2). It also inhibits contraction of the cleavage furrow without disrupting of mitosis or the contractile ring assembly. (S)-(−)-Blebbistatin exhibits rapid and reversible blocking of cell blebbing, as well as disruption of directed cell migration and of cytokinesis in vertebrate cells.
1. Straight, A.F., et al. 2003. Science. 299: 1743-1747. PMID: 12637748
2. Limouze, J., et al. 2004. J. Mus. Res. Cell Motil. 25: 337-41. PMID: 15548862