PNU 112455A hydrochloride CAS: 21886-12-4
MF: C10H11N5O2S•HCl
MW: 301.76
An ATP-competitive inhibitor of CDK2/cyclin E and CDK5/p25.

PNU 112455A hydrochloride (CAS 21886-12-4)

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Alternative Namen: Cdk2/5 Inhibitor
Anwendungen PNU 112455A hydrochloride is an ATP-competitive inhibitor of CDK2/cyclin E and CDK5/p25
CAS Nummer: 21886-12-4
Reinheit: ≥95%
Molekulargewicht: 301.76
Summenformel: C10H11N5O2S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PNU 112455A hydrochloride is a selective and ATP-competitive inhibitor of CDK2/cyclin E (Ki = 2 μM) and CDK5/p35 (p25) (Ki = 2 μM). It binds to the ATP-binding pocket of CDK2 and does not affect the activities of c-met, IGF-1 receptor tyrosine kinase, cAMP-dependent kinase and ERK2 at concentrations as high as 100 μM.


Literaturhinweise

P.M. Clare, et al.; J. Biol. Chem. 276, 48292 (2001).

Aggregatzustand :
Solid
Löslichkeit :
Soluble in DMSO (5 mg/ml,clear solution), and water.
LAGERUNG: :
Store at -20° C
Schmelztemperatur :
293-295° C
Sidepunkt :
578.9° C at 760 mmHg (Predicted)
Brechungsindex :
n20D 1.70 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Deutsche WGK :
3
PubChem CID :
MDL-Nummer :
MFCD00023272
SMILES :
C1=CC(=CC=C1NC2=NC=NC(=C2)N)S(=O)(=O)N.Cl

SDS (MSDS) herunterladen

Analysenzertifikat

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