Noscapine hydrochloride CAS: 912-60-7
MF: C22H23NO7•HCl
MW: 449.88
A bradykinin B and tubulin inhibitor.

Noscapine hydrochloride (CAS 912-60-7)

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Alternative Namen: Narcotine hydrochloride
Anwendungen Noscapine hydrochloride is a bradykinin B and tubulin inhibitor
CAS Nummer: 912-60-7
Reinheit: ≥98%
Molekulargewicht: 449.88
Summenformel: C22H23NO7•HCl
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
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Noscapine hydrochloride is the hydrochloride form of Noscapine. Noscapine is an opioid alkaloid with several actions. Antagonist at Bradykinin B Receptor (bradykinin receptors) (pA2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues. Additionally Noscapine binds to tubulin, arrests cells in mitosis and induces apoptosis. Blocks proliferation of human leukemia and multiple myeloma cells. Furthermore, Noscapine modulates IKK activation, suppressing the NF-κB signaling pathway. Exhibits anti-inflammatory activity. Noscapine hydrochloride is an inhibitor of Tubulin.


Literaturhinweise

1. Mourey, R.J., et al. 1992. Mol. Pharmacol. 42: 619-626.
2. Ye, K., et al. 1998. Proc. Natl. Acad. Sci. U.S.A. 95: 1601-1606.
3. Mahmoudian, M. and Mojaverian, M. 2001. Acta Physiol. Hung. 88: 231-237.
4. Landen, J.W., et al. 2002. Cancer Res. 62: 4109-4114.

Erscheinung :
Powder
Aggregatzustand :
Solid
Löslichkeit :
Soluble in water, and 1eq. HCl (50 mM).
LAGERUNG: :
Desiccate at room temperature
Schmelztemperatur :
221-223° C
Brechungsindex :
n20D ~1.60 (Predicted)
IC50 :
CYP2C19: IC50 = 400.3 nM (human); HepG2: IC50 >1000 nM (human); A549: EC5050 = 25 µM (human)
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
PubChem CID :
Merck Index :
14: 6718
MDL-Nummer :
MFCD00082546
EC-Nummer :
213-014-9
SMILES :
CN1CCC2=CC3=C(C(=C2[[email protected]@H]1[[email protected]]4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OC)OCO3.Cl

SDS (MSDS) herunterladen

Analysenzertifikat

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