L-α-Phosphatidylinositol-3,4,5-trisphosphate, Dipalmitoyl-, Heptaammonium Salt
PI-3,4,5-P3, 7NH4, PIP3, Dipalmitoyl- activates Ca2+-insensitive PKCδ, PKCε, and PKCη isozymes. Binds to the general receptor for phosphoinositide-1 (GRP1) protein through a plekstrin homology (PH) domain. Has also been shown to produce actin reorganization, membrane ruffling and increase motility of NIH/3T3 cells.
Literaturhinweise
1. Toker, A., et al., 1994. Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. The Journal of biological chemistry. 269(51): 32358-67. PMID: 7798235
2. Ireton, K., et al., 1996. A role for phosphoinositide 3-kinase in bacterial invasion. Science (New York, N.Y.). 274(5288): 780-2. PMID: 8864117
3. Derman, M P., et al., 1997. The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C. The Journal of biological chemistry. 272(10): 6465-70. PMID: 9045671
4. Klarlund, J K., et al., 1997. Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Science (New York, N.Y.). 275(5308): 1927-30. PMID: 9072969
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PMID: # 20617170 Fausther-Bovendo H et al. 2010. PLoS Pathog. 6: :e1000975.