CDP 840 hydrochloride CAS: 162542-90-7
MF: C25H27NO2.HCl
MW: 409.95
A selective and potent inhibitor of PDE 4.

CDP 840 hydrochloride (CAS 162542-90-7)

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Alternative Namen: 4-(2-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-phenylethyl)pyridine
Anwendungen CDP 840 hydrochloride is a selective and potent inhibitor of PDE 4
CAS Nummer: 162542-90-7
Molekulargewicht: 409.95
Summenformel: C25H27NO2.HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

CDP 840 hydrochloride is a potent and selective inhibitor of phosphodiesterase 4 (PDE4) (IC50 = 12 nM). This compound competitively inhibits all PDE4 isoenzymes, which in turn prevents the cleavage of phosphodiester bonds found in secondary messenger molecules. This prolongs signal transduction and any subsequent effects.

Aggregatzustand :
Solid
Löslichkeit :
Soluble in DMSO (100 mM).
LAGERUNG: :
Desiccate at room temperature
Brechungsindex :
n20D 1.59 (Predicted)
Optische Aktivität :
α20/D +39°, c = 0.48 in ethanol
IC50 :
TNFalpha release: IC50 = 0.67 nM (human whole blood); Phosphodiesterase 4A: IC50 = 2.1 nM (human); Phosphodiesterase 4B: IC50 = 1.4 nM (human); Phosphodiesterase 4C: IC50 = 4.5 nM (human); Phosphodiesterase 4D: IC50 = 2.1 nM (human)
Ki-Daten :
Phosphodiesterase 4A: Ki= 4 nM (human); Phosphodiesterase 4B: Ki= 60 nM (human); Phosphodiesterase 4C: Ki= 60 nM (human); Phosphodiesterase 4D: Ki= 60 nM (human); [3H]rolipram displacement from PDE4 by RBA: Ki= 16 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
US7546100
PubChem CID :
9885877
SMILES :
COC1=C(C=C(C=C1)C(CC2=CC=NC=C2)C3=CC=CC=C3)OC4CCCC4

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