Bendamustine Hydrochloride CAS: 3543-75-7
MF: C16H21Cl2N3O2•HCl
MW: 394.72
A nitrogen mustard purine analog alkylator.

Bendamustine Hydrochloride (CAS 3543-75-7)

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Alternative Namen: 5-[Bis(2-chloroethyl)-amino]-1-methyl-1H-benzimidazole-2-butanoic Acid Hydrochloride;Ribomustin HCl; Treanda HCl; SDX-105 HCl; 1H-Benzimidazole-2-butanoic acid; 5-[bis(2-chloroethyl)amino]-1-methyl monohydrochloride
Anwendungen Bendamustine Hydrochloride is a nitrogen mustard purine analog alkylator
CAS Nummer: 3543-75-7
Molekulargewicht: 394.72
Summenformel: C16H21Cl2N3O2•HCl
Ergänzende Informationen: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
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Bendamustine Hydrochloride is a small molecule bifunctional DNA alkylating agent, combining a nitrogen mustard functionality with a purine-analog structure. The dense DNA-damaging functionality of Bendamustine differentiates it from other compounds used as antiproliferative agents, and these functionalities are thought to promote cell death through a variety of different pathways including apoptosis and mitotic catastrophe. Accordingly it has been indicated for use in treating proliferations and malignancies refractory to the effects of other DNA alkylators. Efficacy against chronic lymphocytic leukemia is particularly indicated with Bendamustine, presenting a potential intervention upon this notoriously variable and ubiquitous type of malignancy.


Literaturhinweise

1. Balfour, J.A. and Goa, K.L. 2001. Drugs. 61: 631-639. PMID: 11368287
2. Schwänen, C., et al. 2002. Leukemia. 16: 2096-2105. PMID: 12357363
3. Wendtner, C.M., et al. 2004. Semin. Hematol. 41: 224-233. PMID: 15269882
4. Keating, M.J., et al. 2008. Nat Rev Drug Discov. 7: 473-474. PMID: 18511926

Erscheinung :
Crystalline
Aggregatzustand :
Solid
Löslichkeit :
Soluble in methanol, DMSO (≥79 mg/ml) at 25° C, water (≥15 mg/ml) at 25° C, and ethanol (≥17 mg/ml) at 25° C.
LAGERUNG: :
Store at -20° C
Schmelztemperatur :
149-151°C
Sidepunkt :
585.2° C at 760 mmHg (Predicted)
IC50 :
SU-DHL-1 cell proliferation: IC50 = 50 µM
pK Werte :
pKa: 4.50, pKb: 7.24
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
RTECS :
DE1590000
PubChem CID :
Merck Index :
14: 1032
MDL-Nummer :
MFCD01658758
Beilstein-Registernummer :
6031568
SMILES :
CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O.Cl

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Analysenzertifikat

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