Ac-VAD-pNA
Alternative Namen:
Acetyl-Val-Ala-Asp-p-Nitro-Anilide; Ac-Val-Ala-Asp-PNA
Anwendungen
Ac-VAD-pNA is a chromogenic paranitroanilide substrate of caspase-1
Molekulargewicht:
465
Summenformel:
C20H27N5O8
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
Ac-VAD-pNA is a chromogenic paranitroanilide substrate of caspase-1. It is also cleaved by caspase-3, caspase-4, and caspase-7. Similar to amino acids 114-116 (VHD) of the IL-1B precursor, it is an anendogenous substrate of caspase-1. The release of pNA is monitored at 405 nm (ε=9.160M-1cm-1).
Literaturhinweise
- Hypoxia-induced apoptosis of astrocytes is mediated by reduction of Dicer and activation of caspase-1. | Kang, YW., et al. 2020. Cell Biol Int. 44: 1394-1404. PMID: 32129540
Aggregatzustand
:
Solid
Löslichkeit
:
Soluble in DMSO, DMF, and aqueous buffers.
LAGERUNG:
:
Store at room temperature
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
Deutsche WGK
:
3
MDL-Nummer
:
MFCD02259219
SDS (MSDS) herunterladen
SAMPLE Certificate of Analysis (COA)
Ac-VAD-pNA SAMPLE Certificate of AnalysisAnalysenzertifikat
SAMPLE Certificate of Analysis (COA)
Catalog Number:sc-300157
Lot Number:SAMPLE
Product Name:Ac-VAD-pNA
Molecular Formula:C20H27N5O8
Molecular Weight:465
| Test | Specification | Results |
|---|---|---|
| Appearance | White lyophilized powder | |
| Purity (HPLC) | ≥95% |