Molecular structure of Maslinic Acid, CAS Number: 4373-41-5
Maslinic Acid (CAS 4373-41-5)
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Alternate Names:
Crategolic Acid; 2α-Hydroxyoleanoic Acid
Application:
Maslinic Acid is a pentacyclic triterpene with antiproliferative properties
CAS Number:
4373-41-5
Molecular Weight:
472.7
Molecular Formula:
C30H48O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Maslinic Acid is a pentacyclic triterpene with antioxidant and anti-inflammatory properties. Studies indicate that Maslinic Acid blocks the generation of nitric oxide, and inhibits the secretion of IL-6 and TNF-alpha induced by lipopolysaccharides. Maslinic Acid is described to have antiproliferative and anti-HIV properties. In addition, Maslinic Acid is suggested to have a neuroprotective affect by amplifying the expression of astrocytic glutamate transporters and regulating the extracellular glutamate concentration. Research also indicates that Maslinic Acid inhibits the NF-Kbeta signaling pathway and increases the affect of TNF-alpha induced apoptosis.
Maslinic Acid (CAS 4373-41-5) References
- Supressive effect of maslinic acid from pomace olive oil on oxidative stress and cytokine production in stimulated murine macrophages. | Márquez Martín, A., et al. 2006. Free Radic Res. 40: 295-302. PMID: 16484046
- Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple's anticancer activity. | He, X. and Liu, RH. 2007. J Agric Food Chem. 55: 4366-70. PMID: 17488026
- Solution- and solid-phase synthesis and anti-HIV activity of maslinic acid derivatives containing amino acids and peptides. | Parra, A., et al. 2009. Bioorg Med Chem. 17: 1139-45. PMID: 19135380
- Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor alpha by inhibiting NF-kappaB signaling pathway. | Li, C., et al. 2010. Mol Cancer. 9: 73. PMID: 20367887
- Astrocytic glutamate transporter-dependent neuroprotection against glutamate toxicity: an in vitro study of maslinic acid. | Qian, Y., et al. 2011. Eur J Pharmacol. 651: 59-65. PMID: 21118675
- Maslinic acid, a natural phytoalexin-type triterpene from olives--a promising nutraceutical? | Lozano-Mena, G., et al. 2014. Molecules. 19: 11538-59. PMID: 25093990
- Mechanistic Perspectives of Maslinic Acid in Targeting Inflammation. | Yap, WH. and Lim, YM. 2015. Biochem Res Int. 2015: 279356. PMID: 26491566
- Maslinic acid as an effective anticancer agent. | Lin, X., et al. 2018. Cell Mol Biol (Noisy-le-grand). 64: 87-91. PMID: 30084808
- Advances in Research on the Preparation and Biological Activity of Maslinic Acid. | Deng, J., et al. 2021. Mini Rev Med Chem. 21: 79-89. PMID: 32703128
- Maslinic Acid Inhibits Cervical Intraepithelial Neoplasia by Suppressing Interleukin- 6 and Enhancing Apoptosis in a Mouse Model. | Chen, J. and Wang, L. 2022. Anticancer Agents Med Chem. 22: 579-585. PMID: 34477530
- Maslinic acid activates renal AMPK/SIRT1 signaling pathway and protects against diabetic nephropathy in mice. | Gao, H. and Wu, H. 2022. BMC Endocr Disord. 22: 25. PMID: 35042497
- Maslinic Acid Inhibits the Growth of Malignant Gliomas by Inducing Apoptosis via MAPK Signaling. | Wang, Y., et al. 2022. J Oncol. 2022: 3347235. PMID: 35799612
- Maslinic Acid: A New Compound for the Treatment of Multiple Organ Diseases. | He, Y., et al. 2022. Molecules. 27: PMID: 36557864
- Maslinic acid exerts anticancer effects by targeting cancer hallmarks. | Ooi, KX., et al. 2023. Phytomedicine. 110: 154631. PMID: 36621168
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Alox12e.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Maslinic Acid, 1 mg | sc-221873 | 1 mg | $62.00 | |||
Maslinic Acid, 5 mg | sc-221873A | 5 mg | $200.00 |