Molecular structure of Bis(maltolato)oxovanadium(IV), CAS Number: 38213-69-3
Bis(maltolato)oxovanadium(IV) (CAS 38213-69-3)
Alternate Names:
2-methyl-4-oxopyran-3-olate; oxovanadium(2+); Bmov(IV)
Application:
Bis(maltolato)oxovanadium(IV) is A potent insulin mimic
CAS Number:
38213-69-3
Molecular Weight:
317.15
Molecular Formula:
C12H10O7V
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Bis(maltolato)oxovanadium(IV) is a potent insulin mimic. Results have shown that BMOV significantly decreases plasma glucose levels in diabetic rats at all given doses, and restores hyperglycemic values to normal. Bis(maltolato)oxovanadium(IV) inhibits protein tyrosine phosphatases.
Bis(maltolato)oxovanadium(IV) (CAS 38213-69-3) References
- Effects of vanadium complexes with organic ligands on glucose metabolism: a comparison study in diabetic rats. | Reul, BA., et al. 1999. Br J Pharmacol. 126: 467-77. PMID: 10077240
- Bis(maltolato)oxovanadium(IV) inhibits the activity of PTP1B in Zucker rat skeletal muscle in vivo. | Mohammad, A., et al. 2002. Mol Cell Biochem. 229: 125-8. PMID: 11936837
- Mechanisms by which bis(maltolato)oxovanadium(IV) normalizes phosphoenolpyruvate carboxykinase and glucose-6-phosphatase expression in streptozotocin-diabetic rats in vivo. | Marzban, L., et al. 2002. Endocrinology. 143: 4636-45. PMID: 12446591
- Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle. | Cantley, LC., et al. 1977. J Biol Chem. 252: 7421-3. PMID: 144127
- Calorimetric studies of the interaction between the insulin-enhancing drug candidate bis(maltolato)oxovanadium(IV) (BMOV) and human serum apo-transferrin. | Bordbar, AK., et al. 2009. J Inorg Biochem. 103: 643-7. PMID: 19056126
- Bis(maltolato)-oxovanadium (IV)-induced phosphorylation of PKB, GSK-3 and FOXO1 contributes to its glucoregulatory responses (review). | Vardatsikos, G., et al. 2009. Int J Mol Med. 24: 303-9. PMID: 19639221
- Antidiabetic Bis-Maltolato-OxoVanadium(IV): conversion of inactive trans- to bioactive cis-BMOV for possible binding to target PTP-1B. | Scior, T., et al. 2009. Drug Des Devel Ther. 2: 221-31. PMID: 19920909
- Vibrational spectra of bis(maltolato)oxovanadium(IV): a potent insulin mimetic agent. | Parajón-Costa, BS. and Baran, EJ. 2011. Spectrochim Acta A Mol Biomol Spectrosc. 78: 133-5. PMID: 20934377
- Effect of bis(maltolato)oxovanadium (IV) (BMOV) on selenium nutritional status in diabetic streptozotocin rats. | Sanchez-Gonzalez, C., et al. 2012. Br J Nutr. 108: 893-9. PMID: 22085676
- Insulin-mimetic effects of vanadate. Possible implications for future treatment of diabetes. | Shechter, Y. 1990. Diabetes. 39: 1-5. PMID: 2210051
- Exposure to bis(maltolato)oxovanadium(IV) increases levels of hepcidin mRNA and impairs the homeostasis of iron but not that of manganese. | Sánchez-González, C., et al. 2014. Food Chem Toxicol. 73: 113-8. PMID: 25168077
- Bis(maltolato)oxovanadium(IV) Induces Angiogenesis via Phosphorylation of VEGFR2. | Parma, L., et al. 2020. Int J Mol Sci. 21: PMID: 32629855
- Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats. | Sánchez-González, C., et al. 2022. Biology (Basel). 11: PMID: 35741335
- Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. | Cohen, N., et al. 1995. J Clin Invest. 95: 2501-9. PMID: 7769096
- Bis(maltolato)oxovanadium(IV) attenuates hyperinsulinemia and hypertension in spontaneously hypertensive rats. | Bhanot, S., et al. 1994. Diabetes. 43: 857-61. PMID: 8013747
Inhibitor of:
Cdc25A, NIPA1, PTP, PTPδ, and PTPDC1.Activator of:
PTPRQ.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bis(maltolato)oxovanadium(IV), 250 mg | sc-210943 | 250 mg | $372.00 |