ZNF508 Inhibitors

ADNP homeobox 2, often abbreviated as ADNP2, is a protein that belongs to a family of homeobox proteins known for their roles in regulating patterns of anatomical development (morphogenesis) and ensuring the proper functioning of genetic material during the life cycle of an organism. Homeobox genes encode transcription factors characterized by the presence of a 60-amino acid helix-turn-helix DNA-binding domain, known as the homeodomain, which allows them to control the expression of target genes.ADNP2 is a homologue of the Activity-Dependent Neuroprotective Protein (ADNP), which is essential for brain formation and function, playing a pivotal role in neurodevelopment and neuroprotection. The ADNP family proteins are involved in chromatin remodeling and regulation of gene expression, which are critical for cell differentiation, proliferation, and survival.

While detailed functions of ADNP2 are less characterized than its homologue ADNP, which is known to play a role in the development of the nervous system and is implicated in autism spectrum disorders and intellectual disabilities, ADNP2 has been suggested to potentially have similar regulatory functions given its structural similarities. These functions may include involvement in neural development and contributing to the transcriptional regulation of genes necessary for cell identity and fate determination.Mutations or alterations in the expression of ADNP2, as with other homeobox proteins, could have significant developmental implications and might be associated with neurological disorders. However, the specific pathways and target genes regulated by ADNP2 are not fully elucidated, necessitating additional research to uncover its exact role in development and disease.