Vmn2r67 Inhibitors
Vmn2r67 can modulate the activity of this protein through various biochemical pathways. Bicuculline, known to antagonize GABA receptors, can inhibit Vmn2r67 activity by altering the inhibitory tone within neural circuits that process pheromonal cues, potentially reducing the excitability of neurons that express Vmn2r67. Similarly, tetrodotoxin exerts its effects by blocking voltage-gated sodium channels, which leads to a decrease in neuronal action potential firing. This blockade can result in diminished activity of Vmn2r67-expressing neurons. CNQX and D-AP5, which antagonize AMPA and NMDA receptors respectively, can limit excitatory neurotransmission. This reduction in excitatory input can decrease the functional output of neurons that express Vmn2r67, leading to a lower responsiveness to relevant stimuli.
Vmn2r67 indirectly through systemic physiological changes. For example, nifedipine and losartan, which act on calcium channels and angiotensin II receptors respectively, can alter blood pressure and consequently may affect the blood flow to olfactory regions where Vmn2r67-expressing neurons reside. This can result in a less optimal environment for the function of these neurons. Meclofenamic acid, by inhibiting cyclooxygenase, can affect prostaglandin levels, which in turn can modulate the sensitivity of the olfactory system and thus influence the activity of Vmn2r67. In a different aspect of neural regulation, amitriptyline and haloperidol, which affect the reuptake of neurotransmitters and block dopamine receptors respectively, can modulate the central nervous system's processing of sensory information. These alterations in neurotransmitter dynamics can lead to a change in the activity of Vmn2r67-expressing neurons. Lastly, ketamine, another NMDA receptor antagonist, can reduce neuronal excitability, which can lead to a decrease in Vmn2r67 neuron activity due to lowered synaptic activation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(+)-Bicuculline | 485-49-4 | sc-202498 sc-202498A | 50 mg 250 mg | $80.00 $275.00 | ||
Bicuculline is a competitive antagonist of GABA receptors. Since Vmn2r67 is a vomeronasal type-2 receptor that might detect pheromonal cues, GABAergic inhibition could indirectly inhibit Vmn2r67 by affecting neural circuits that process these signals, leading to a reduction in the activity of neurons expressing Vmn2r67. | ||||||
Captopril | 62571-86-2 | sc-200566 sc-200566A | 1 g 5 g | $48.00 $89.00 | 21 | |
Captopril is an inhibitor of angiotensin-converting enzyme (ACE). By reducing the production of angiotensin II, captopril could decrease blood pressure and indirectly affect the olfactory system, potentially altering the activity of Vmn2r67 receptors, which are involved in pheromone detection. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $66.00 | 4 | |
Omeprazole is a proton pump inhibitor that reduces gastric acid production. Changes in the internal milieu caused by altered digestive chemistry could indirectly influence the olfactory epithelium and, by extension, Vmn2r67 receptor activity due to systemic pH alterations. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is a calcium channel blocker. By inhibiting calcium influx, nifedipine could reduce neurotransmitter release in neurons expressing Vmn2r67, thereby inhibiting these neurons' ability to respond to stimuli. | ||||||
Losartan | 114798-26-4 | sc-353662 | 100 mg | $127.00 | 18 | |
Losartan is an angiotensin II receptor antagonist that can lower blood pressure. By altering cardiovascular function and potentially the blood flow to olfactory areas, losartan could indirectly inhibit the activity of neurons expressing Vmn2r67. | ||||||
Amitriptyline Hydrochloride | 549-18-8 | sc-210801 | 1 g | $196.00 | ||
Amitriptyline is a tricyclic antidepressant that blocks the reuptake of neurotransmitters. It could indirectly inhibit Vmn2r67 by modulating the central nervous system and altering the processing of sensory information, including pheromones. | ||||||
6-Cyano-7-nitroquinoxaline-2,3-dione | 115066-14-3 | sc-505104 | 10 mg | $204.00 | 2 | |
CNQX is an AMPA receptor antagonist that can inhibit excitatory neurotransmission. By suppressing excitatory inputs, it may indirectly inhibit the neural pathways in which Vmn2r67-expressing neurons participate, leading to reduced Vmn2r67 activity. | ||||||
Meclofenamic Acid | 644-62-2 | sc-211780 | 5 mg | $394.00 | ||
Meclofenamic acid is a nonsteroidal anti-inflammatory drug that inhibits cyclooxygenase. By reducing prostaglandin synthesis, it could affect the sensitivity of the olfactory system and indirectly inhibit neurons that express Vmn2r67. | ||||||
Haloperidol | 52-86-8 | sc-507512 | 5 g | $190.00 | ||
Haloperidol is a dopamine receptor antagonist commonly used as an antipsychotic. Dopamine modulation can influence olfactory processing, and haloperidol could indirectly inhibit Vmn2r67 by altering dopamine signaling in the brain. | ||||||