Date published: 2026-7-6

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TRA-1-81 Activators

The chemical class termed TRA-1-81 Activators encompasses a range of compounds that are specifically known or designed to upregulate or enhance the expression of the TRA-1-81 protein, a surface antigen predominantly associated with pluripotent stem cells. The distinctive feature of these activators lies in their targeted mechanism of action, which focuses on modulating cellular pathways or genetic mechanisms to increase the levels of TRA-1-81. This protein, serving as a marker for pluripotency, becomes an essential focal point for research in cellular biology and developmental studies. Compounds within this class can vary widely in their structure and origin, encompassing small molecules, synthetic compounds, or naturally occurring substances. Each of these activators may employ different biochemical mechanisms to achieve the upregulation of TRA-1-81. These mechanisms could involve alterations in gene expression, epigenetic modifications, or the modulation of intracellular signaling pathways that directly or indirectly affect the levels of TRA-1-81.

The research interest in TRA-1-81 Activators primarily revolves around their utility in studying stem cell biology and development. By manipulating the expression of TRA-1-81, scientists can gain insights into the mechanisms governing stem cell pluripotency and differentiation. Understanding how these activators work helps in dissecting the complex networks of gene regulation and signal transduction involved in stem cell maintenance. This knowledge is crucial for fundamental research aimed at elucidating the intricate details of cell development and pluripotency. Moreover, these activators are valuable tools in cellular research, offering a means to control and observe the behavior of stem cells under various experimental conditions. By influencing TRA-1-81 expression, researchers can monitor and study changes in the pluripotent state of stem cells, aiding in the exploration of fundamental biological processes. The study of TRA-1-81 Activators, therefore, represents a significant area of interest for scientists focusing on the basic understanding of stem cell biology and the molecular mechanisms underlying cellular pluripotency and development.

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Influences cell differentiation and is involved in the regulation of gene expression in stem cells.

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

A DNA methyltransferase inhibitor, alters epigenetic marks and can induce pluripotency.

Thiazovivin

1226056-71-8sc-361380
sc-361380A
10 mg
25 mg
$284.00
$634.00
15
(1)

A ROCK inhibitor, enhances cell survival and is used in stem cell culture for maintaining pluripotency.

Valproic Acid

99-66-1sc-213144
10 g
$87.00
9
(1)

A histone deacetylase inhibitor, it has been shown to enhance reprogramming efficiency in iPSC generation.

Lithium

7439-93-2sc-252954
50 g
$214.00
(0)

Influences Wnt signaling pathway, which plays a role in stem cell maintenance and pluripotency.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$78.00
$153.00
$740.00
$1413.00
$2091.00
73
(3)

Activates cAMP signaling and has been used in combination with other factors for iPSC generation.