TKTL2 Activators
TKTL2 activators are compounds that interact with the metabolic and enzymatic milieu of the cell to modulate the activity of Transketolase-like protein 2. These activators include essential cofactors, substrates, and metabolic intermediates that engage with TKTL2 either by enhancing its catalytic efficiency, providing substrate availability, or by stabilizing the enzyme structure. For example, thiamine pyrophosphate is an essential coenzyme that binds directly to TKTL2, and its availability is directly proportional to the activation of TKTL2's transketolase activity.
Similarly, zinc sulfate and magnesium chloride contribute to the structural integrity and catalytic competence of TKTL2. The presence of substrates such as fructose-6-phosphate, xylulose-5-phosphate, and sedoheptulose-7-phosphate in adequate concentrations ensures that TKTL2 is catalytically active within the pentose phosphate pathway, facilitating the flow through this crucial metabolic route. Further, compounds like NADPH play a supportive role by maintaining a reduced environment that is favorable for the anabolic reactions within the pentose phosphate pathway in which TKTL2 participates.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thiamine pyrophosphate | 154-87-0 | sc-215966 sc-215966A sc-215966B sc-215966C sc-215966D | 1 g 5 g 25 g 100 g 1 kg | $32.00 $95.00 $284.00 $1126.00 $5906.00 | 1 | |
Coenzyme form of vitamin B1 and an essential cofactor for transketolase enzymes, directly required for their enzymatic activity. Increasing its availability can enhance TKTL2 function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Essential trace element that can act as a cofactor for various enzymes, potentially improving the structural stability of TKTL2 and hence its enzymatic activity. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $27.00 $34.00 $47.00 $123.00 | 2 | |
Magnesium acts as a cofactor for many enzymes including those involved in phosphorylation. It may indirectly enhance TKTL2 activity by stabilizing its active conformation. | ||||||
β-Nicotinamide adenine dinucleotide phosphate | 53-59-8 | sc-215560 sc-215560A | 100 mg 250 mg | $114.00 $198.00 | ||
Nicotinamide adenine dinucleotide phosphate, reduced form, which is utilized in biosynthetic reactions. Its availability is crucial for the function of TKTL2 in the pentose phosphate pathway. | ||||||
D-Erythrose 4-phosphate sodium salt | 103302-15-4 | sc-214801 sc-214801B sc-214801A sc-214801C | 5 mg 10 mg 25 mg 100 mg | $190.00 $307.00 $525.00 $1632.00 | 2 | |
A product of the transketolase reaction which TKTL2 may utilize; enriching its availability can potentially increase TKTL2 pathway flux. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $32.00 $42.00 $62.00 $108.00 $184.00 $724.00 $2050.00 | 2 | |
An important molecule in the TCA cycle; may indirectly affect TKTL2 by altering energy metabolism and redox balance, thus potentially influencing its activity. | ||||||