SUMO-1 Inhibitors
Common SUMO-1 Inhibitors include, but are not limited to Ginkgolic acid C15:1 CAS 22910-60-7, Anacardic Acid CAS 16611-84-0, Spectinomycin dihydrochloride pentahydrate CAS 22189-32-8, Tunicamycin CAS 11089-65-9 and Ivermectin CAS 70288-86-7.
The Small Ubiquitin-like Modifier (SUMO) proteins, among which SUMO-1 is a prominent member, are involved in the post-translational modification of proteins. This process, known as SUMOylation, entails the covalent attachment of SUMO moieties to target proteins, thereby altering their stability, localization, or activity. SUMOylation has been recognized as a critical regulatory mechanism that affects a multitude of cellular processes, including DNA repair, transcriptional regulation, nuclear-cytosolic transport, and cell cycle progression. SUMO-1, in particular, plays a pivotal role in the cellular stress response, as well as in the maintenance of genome integrity.
SUMO-1 inhibitors are compounds specifically designed to target and obstruct the SUMOylation process facilitated by SUMO-1. These inhibitors typically work by impeding the enzymes responsible for attaching SUMO-1 to its target proteins or by preventing the interaction between SUMO-1 and these targets directly. By disrupting the SUMOylation process, SUMO-1 inhibitors can significantly affect the post-translational modification landscape within cells.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ginkgolic acid C15:1 | 22910-60-7 | sc-235249 | 5 mg | $306.00 | 2 | |
Ginkgolic acid is an inhibitor of the SUMO E1-activating enzyme, which might lead to reduced sumoylation and potentially down-regulate SUMO-1 expression. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
Similar to ginkgolic acid, anacardic acid inhibits the SUMO E1-activating enzyme, potentially influencing SUMO-1 levels. | ||||||
Spectinomycin dihydrochloride pentahydrate | 22189-32-8 | sc-203279 sc-203279A | 5 g 10 g | $82.00 $120.00 | 9 | |
It can disrupt protein synthesis and might indirectly affect the synthesis and expression of SUMO-1. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, leading to ER stress. This might indirectly influence SUMO-1 expression. | ||||||
Ivermectin | 70288-86-7 | sc-203609 sc-203609A | 100 mg 1 g | $56.00 $75.00 | 2 | |
Ivermectin is believed to interfere with SUMOylation, potentially reducing SUMO-1 levels. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
It has been shown to modulate various signaling pathways, and its effect on SUMOylation might down-regulate SUMO-1. | ||||||
2-D08 | 144707-18-6 | sc-507405 | 5 mg | $150.00 | ||
2-D08 is a SUMOylation inhibitor and can potentially down-regulate SUMO-1 by inhibiting its conjugation to target proteins. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
PYR-41 inhibits ubiquitin activation, which might indirectly influence SUMO-1 levels and SUMOylation processes. | ||||||
Sulfamethazine | 57-68-1 | sc-220159 | 25 g | $57.00 | 1 | |
This compound has been identified as a potential SUMOylation inhibitor, possibly influencing SUMO-1 levels. | ||||||
Pentamidine | 100-33-4 | sc-208158 sc-208158A | 25 mg 50 mg | $373.00 $557.00 | ||
This antiparasitic drug might interfere with SUMOylation and potentially influence SUMO-1 levels. | ||||||