SmB Inhibitors
Chemical inhibitors of the SmB protein function primarily by disrupting the assembly and operation of the spliceosome, a complex molecular machine that is crucial for the splicing of precursor messenger RNA. Compounds such as Alsterpaullone exert their effects by targeting cyclin-dependent kinases, which are enzymes that play a significant role in cell cycle regulation and consequently in the spliceosome assembly process. The inhibition of these kinases can lead to disruptions in the splicing events that SmB is involved in. Isoginkgetin also blocks spliceosome assembly, preventing SmB from fulfilling its role in RNA splicing.
Other inhibitors, like Pladienolide B and its derivative E7107, Meayamycin B, Madrasin, Spliceostatin A, and Herboxidiene, target the SF3b complex, a central component of the spliceosome that is closely associated with SmB. By binding to this complex, these molecules disrupt its normal function, which in turn impedes the functioning of SmB. The consequences of such inhibition are a direct impairment of the spliceosome's RNA splicing capability. Additionally, Tetrocarcin A is known to affect the spliceosome's activity by targeting the same SF3b complex, again leading to the inhibition of SmB's role in the splicing process. Each of these chemical inhibitors, although differing in their specific mechanisms of action and points of interaction within the spliceosome, ultimately converge on a common outcome: the inhibition of SmB protein's function in the RNA splicing pathway.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
Alsterpaullone is a potent inhibitor of cyclin-dependent kinases (CDKs), which are essential for the regulation of the cell cycle. Since SmB protein is involved in spliceosome assembly, which is tightly connected to the cell cycle, inhibition of CDKs by Alsterpaullone can lead to a disruption of splicing events, thereby affecting the functionality of SmB. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
Pladienolide B binds to the SF3b complex, which is a critical component of the spliceosome where SmB protein operates. By binding to SF3b, Pladienolide B disrupts the normal assembly and function of the spliceosome, thereby inhibiting the role SmB plays in RNA splicing. | ||||||
Isoginkgetin | 548-19-6 | sc-507430 | 5 mg | $225.00 | ||
Isoginkgetin is a pre-mRNA splicing inhibitor that impedes the spliceosome assembly process. With SmB being integral to the spliceosome, the inhibition of assembly by Isoginkgetin results in a functional inhibition of SmB. | ||||||
Madrasin | 374913-63-0 | sc-507563 | 100 mg | $750.00 | ||
Madrasin selectively inhibits the splicing factor 3B subunit 1 (SF3B1), a part of the SF3b complex. Since SmB is associated with the spliceosome, the inhibition of SF3B1 by Madrasin can disrupt spliceosome function and thereby inhibit SmB activity. | ||||||
Spliceostatin A | 391611-36-2 | sc-507481 | 1 mg | $1800.00 | ||
Spliceostatin A is a potent inhibitor of the spliceosome, which binds to the SF3b complex and impairs its function. By directly targeting the spliceosome, Spliceostatin A inhibits the functional activities of SmB. | ||||||
Herboxidiene | 142861-00-5 | sc-506378 | 1 mg | $1009.00 | ||
Herboxidiene, also known as GEX1A, targets the SF3b complex within the spliceosome. The disruption of SF3b function by Herboxidiene leads to an inhibition of SmB's role in RNA splicing. | ||||||
FR901464 | 146478-72-0 | sc-507352 | 5 mg | $1800.00 | ||
FR901464 is known to bind the spliceosome, affecting its function. As SmB is a core component of the spliceosome, the action of FR901464 can inhibit the splicing activity and thus the function of SmB. | ||||||