robo4 Activators
The putative chemical activators presented in the list contribute to a nuanced modulation of cellular signaling pathways, unraveling a sophisticated landscape that intricately influences Robo4 activity. Each compound within the repertoire is strategically designed to target specific cellular processes or signaling cascades that intersect with Robo4's pivotal roles in endothelial cell function and vascular stability. Among the compounds listed, db-cAMP and Forskolin stand out for their ability to elevate intracellular cAMP levels. This elevation augments PKA activity, thereby leading to an increased expression or activity of proteins involved in the angiogenesis pathway, including Robo4. This suggests a finely tuned regulatory mechanism where enhanced cAMP levels play a contributory role in modulating Robo4 function. In contrast, compounds like anisomycin and PMA operate by activating stress or protein kinase pathways, triggering broader cellular responses that may encompass the upregulation of Robo4. This underscores the multifaceted nature of cellular signaling, highlighting the intricate cross-talk between pathways that govern cellular behavior.
Moreover, hormone analogs or agonists such as β-Estradiol and HGF agonists provide additional layers of complexity. These compounds underscore the diverse ways in which Robo4 activity can be indirectly modulated by signaling molecules with far-reaching effects within the cell. Hormones and growth factors, with their pivotal roles in orchestrating cellular responses, exert a significant influence on Robo4 activity, particularly in the context of endothelial cell function and vascular stability. Collectively, these chemicals present a spectrum of approaches to modulate Robo4 indirectly by exerting primary actions on different signaling pathways. This illustrates the complex nature of cellular regulation, where changes in one pathway dynamically influence the activity of another, reflecting the intricate interconnectedness inherent in cellular signaling networks.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor known to activate stress-activated protein kinases (SAPKs). Activation of these kinases can lead to cellular stress responses that may upregulate Robo4 expression as part of a compensatory mechanism in endothelial cells, indirectly enhancing Robo4 signaling. | ||||||
L-phenylephrine | 59-42-7 | sc-295315 sc-295315A | 5 g 25 g | $181.00 $492.00 | 2 | |
As an α1-adrenergic receptor agonist, phenylephrine can stimulate downstream signaling pathways that may include upregulation of molecules within the Robo4 signaling axis, potentially increasing Robo4 activity in vascular endothelial cells. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a cAMP analog that can permeate cell membranes and activate protein kinase A (PKA). PKA activation can lead to the upregulation of various proteins, potentially including Robo4, due to enhanced cellular signaling. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride is known to activate the Wnt signaling pathway, which could upregulate genes related to angiogenesis and vascular stability, including potentially Robo4, by inhibiting GSK-3β and stabilizing β-catenin. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC) which is involved in a variety of cellular responses. Activation of PKC has been implicated in the modulation of cell adhesion and motility, processes where Robo4 might be indirectly upregulated as part of the cellular response. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly activates adenylyl cyclase, increasing intracellular levels of cAMP. Elevated cAMP can enhance the activity of PKA and Epac, which might lead to upregulation or activation of proteins, including potentially Robo4, involved in endothelial cell function and vascular stability. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A derivative of vitamin A, all-trans retinoic acid, regulates gene expression by activating nuclear receptors. It can induce the differentiation of various cell types and may promote the expression of Robo4 in endothelial cells as part of a complex network of genes involved in vascular system development. | ||||||
Beclomethasone Dipropionate | 5534-09-8 | sc-210864 | 250 mg | $52.00 | ||
Beclomethasone, a glucocorticoid, can modulate the expression of numerous genes. While typically associated with anti-inflammatory action, it may have a role in upregulating genes like Robo4 that are part of the cellular response to inflammation and injury in vascular tissues. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
β-Estradiol is known to exert a wide array of genomic effects, including the modulation of angiogenesis-related genes. It may enhance Robo4 signaling indirectly by upregulating its expression as part of a broader influence on vascular endothelial cells. | ||||||