RNA pol σ H Activators
The class of RNA pol σ H Activators is conceptualized as a group of chemicals that could potentially influence the activity of RNA polymerase sigma factor H (σ H) indirectly. Since σ H is involved in the transcriptional response to stress in bacteria, the activation of σ H is closely linked to the bacterial cell's ability to respond to various stressors. The chemicals listed are not direct activators of σ H but rather influence cellular pathways and stress responses that could, in turn, modulate the activity of σ H.
Compounds like Rifampicin and Ciprofloxacin, known for their antibiotic properties, can induce bacterial stress responses that may indirectly influence σ H activity. The presence of stress-inducing agents such as Mitomycin C, which causes DNA damage, and Heat Shock Activators like Geldanamycin, further demonstrate the potential indirect impact on σ H through the induction of cellular stress pathways. Ethanol and high concentrations of Sodium Chloride illustrate the effect of general and osmotic stress on bacterial cells, potentially leading to the activation of σ H as part of the stress response. Oxidative stress inducers like Hydrogen Peroxide and Diamide exemplify how changes in the cellular redox state can impact σ H activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Inhibits bacterial RNA polymerase, potentially affecting σ H activity indirectly through stress response pathways. | ||||||
Ciprofloxacin | 85721-33-1 | sc-217900 | 1 g | $43.00 | 8 | |
A DNA gyrase inhibitor, may induce stress responses that could indirectly influence σ H activity. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Causes DNA damage, potentially affecting σ H activity through the induction of DNA stress response pathways. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Induces heat shock proteins, potentially affecting σ H activity indirectly through stress response pathways. | ||||||
Sodium Chloride | 7647-14-5 | sc-203274 sc-203274A sc-203274B sc-203274C | 500 g 2 kg 5 kg 10 kg | $19.00 $30.00 $60.00 $110.00 | 15 | |
Induces osmotic stress, potentially affecting σ H activity through osmotic stress response pathways. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Generates oxidative stress, potentially influencing σ H activity through oxidative stress response pathways. | ||||||
4,N,N-Trimethylaniline | 99-97-8 | sc-238996 sc-238996A | 100 ml 500 ml | $44.00 $128.00 | ||
Induces oxidative stress, potentially affecting σ H activity indirectly through the redox-regulatory pathways. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $43.00 $85.00 $158.00 | 7 | |
Induces nitrosative stress, potentially affecting σ H activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Excess zinc can cause metal stress, potentially influencing σ H activity through metal stress response pathways. | ||||||
Paraquat chloride | 1910-42-5 | sc-257968 | 250 mg | $168.00 | 7 | |
Generates superoxide radicals, potentially affecting σ H activity through oxidative stress pathways. | ||||||