Ribosomal Protein S18 Inhibitors
Chemical inhibitors of Ribosomal Protein S18 can disrupt the protein's function through various mechanisms, all of which target the process of protein synthesis where Ribosomal Protein S18 plays a critical role. Anisomycin, for instance, specifically blocks peptide bond formation at the ribosome, effectively stalling the translation process that Ribosomal Protein S18 is part of. Similarly, Cycloheximide acts by preventing the translocation steps in protein synthesis, thereby stopping the ribosome's movement along the mRNA strand, a step where Ribosomal Protein S18 is essential. Ricin goes a step further by depurinating a key adenine residue from the 28S rRNA of the 60S ribosomal subunit, which is a direct attack on the ribosome's structural integrity, affecting Ribosomal Protein S18's contribution to ribosomal function. α-Sarcin cleaves a specific bond in the 28S rRNA, preventing the binding of elongation factors to the ribosome and thus inhibiting the protein synthesis process that Ribosomal Protein S18 facilitates.
Furthermore, Tenuazonic Acid inhibits the peptidyl transferase activity, which is a catalytic function of the ribosome and where Ribosomal Protein S18 is active. Homoharringtonine and Harringtonine both inhibit protein synthesis by preventing the initial elongation step and the peptidyl transferase reaction, respectively, which directly compromises the role of Ribosomal Protein S18. Emetine and Puromycin disrupt translation by blocking ribosome translocation and causing premature chain termination, which would not be possible without affecting the functioning of Ribosomal Protein S18. Blasticidin S and Pactamycin inhibit protein synthesis by binding to the peptidyl transferase component and blocking initiation complex formation, respectively, which impairs Ribosomal Protein S18's role in the accurate translation of proteins. Lastly, Fusidic Acid targets protein synthesis by preventing the dissociation of elongation factor G (EF-G) from the ribosome, thereby halting the translocation process where Ribosomal Protein S18 is involved.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a pyrrolidine antibiotic that inhibits protein synthesis by blocking peptide bond formation at the level of the 80S ribosome, which includes Ribosomal Protein S18. This inhibition compromises the ribosome's function and consequently inhibits Ribosomal Protein S18's role in translation. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide is a glutarimide antibiotic that inhibits eukaryotic protein synthesis by preventing translocation steps in protein synthesis, which in turn affects the functionality of Ribosomal Protein S18 as it is directly involved in the protein translation process. | ||||||
α-Sarcin | 86243-64-3 | sc-204427 | 1 mg | $462.00 | 6 | |
α-Sarcin is a ribosome-inactivating protein that cleaves a specific phosphodiester bond in the 28S rRNA, hindering the elongation factor's binding to the ribosome and thus inhibiting protein synthesis, which affects Ribosomal Protein S18's role in translation. | ||||||
Homoharringtonine | 26833-87-4 | sc-202652 sc-202652A sc-202652B | 1 mg 5 mg 10 mg | $52.00 $125.00 $182.00 | 11 | |
Homoharringtonine is a cephalotaxine ester that inhibits protein synthesis by preventing the initial elongation step of translation, which interferes with Ribosomal Protein S18's role in this essential process. | ||||||
Emetine | 483-18-1 | sc-470668 sc-470668A sc-470668B sc-470668C | 1 mg 10 mg 50 mg 100 mg | $440.00 $900.00 $1400.00 $2502.00 | ||
Emetine is an alkaloid derived from the ipecac root that inhibits protein synthesis by blocking translocation of the ribosome along mRNA, thus directly inhibiting the functionality of Ribosomal Protein S18 in the translation mechanism. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $166.00 $322.00 | 436 | |
Puromycin is an aminonucleoside antibiotic that causes premature chain termination during translation by acting as an analog of the 3'-end of aminoacyl-tRNA, which would impair the function of Ribosomal Protein S18 in protein synthesis. | ||||||
Blasticidin S Hydrochloride | 3513-03-9 | sc-204655A sc-204655 | 25 mg 100 mg | $367.00 $520.00 | 20 | |
Blasticidin S is a nucleoside antibiotic that inhibits protein synthesis by binding to the peptidyl transferase component of the ribosome, influencing Ribosomal Protein S18's role in translation by preventing proper peptide bond formation. | ||||||
Harringtonin | 26833-85-2 | sc-204771 sc-204771A sc-204771B sc-204771C sc-204771D | 5 mg 10 mg 25 mg 50 mg 100 mg | $250.00 $367.00 $548.00 $730.00 $980.00 | 30 | |
Harringtonine is an alkaloid that inhibits protein synthesis by blocking the peptidyl transferase reaction of the ribosome, which then disrupts the function of Ribosomal Protein S18 in the translation process. | ||||||
Fusidic acid | 6990-06-3 | sc-215065 | 1 g | $292.00 | ||
Fusidic Acid is a steroid antibiotic that inhibits protein synthesis by preventing the turnover of elongation factor G (EF-G) from the ribosome, which in turn inhibits the role of Ribosomal Protein S18 in the translocation step of protein synthesis. | ||||||