Rag B Inhibitors

Rag B is involved in the amino acid-mediated activation of mTORC1, a central component of cellular growth and metabolism. The above-mentioned compounds do not inhibit Rag B directly but affect the signaling pathways that Rag B is part of. They include inhibitors of mTOR itself, activators of AMPK, and other compounds that modulate cellular energy status and nutrient sensing pathways that converge on mTORC1.

The chemical class of indirect Rag B inhibitors includes agents that target various aspects of the mTOR pathway, either upstream or downstream of Rag B. These compounds can affect the activity of mTORC1 by changing the activation state of upstream kinases, altering the availability of cellular energy, or by directly inhibiting mTORC1 and mTORC2 complexes. They work by modulating the signaling network that controls cell growth and metabolism, which are processes that are critically dependent on the function of Rag B in amino acid sensing.