PRP6 Inhibitors

PRP6 inhibitors, as defined here, are inhibtors that can indirectly interfere with the function of PRP6 by targeting the spliceosome or splicing-related processes. These inhibitors do not directly bind to PRP6 but affect the complex within which PRP6 operates. The majority of the inhibitors interact with the SF3B complex, a crucial component of the spliceosome necessary for the recognition of branch point sequences in pre-mRNA. By binding to this complex, inhibtiors can disrupt the proper assembly and function of the spliceosome. This disruption can affect the participation of PRP6 in the splicing process, as PRP6 is a component of the U5 snRNP involved in spliceosome assembly and splicing catalysis.

The action of these inhibitors can lead to the accumulation of unspliced pre-mRNA or the generation of aberrantly spliced mRNAs, thereby impacting gene expression. Inhibitors are part of the same class of splicing inhibitors that target the SF3b complex and thus indirectly impact PRP6 function. They also disrupt the splicing process, which can indirectly affect PRP6. Lastly, PRP6 inhibitors affect RNA helicase eIF4A and can lead to downstream effects on mRNA splicing and maturation, which can, in turn, impact PRP6 function.