Potassium Channel Modulators

Santa Cruz Biotechnology now offers a broad range of Potassium Channel Modulators. Potassium Channel Modulators include any agent that blocks, activates, or modifies a potassium channel resulting in an alteration of the flow of potassium through the channel. Potassium channels are ubiquitous in biological systems and function as a control for the resting potential of cells. Potassium channels are notably important in neuronal and muscular cells, and their dysfunction has implications in many diseases including diabetes. Our popular products such as Glyburide (Glibenclamide), Tolazamide, and Flupirtine Maleate are typically available for immediate shipment.

indicates a highly recommended product based on customer preference.

PRODUCT NAME/Application CAS Catalog # QUANTITY Price Citations RATING
Glyburide (Glibenclamide)
Glyburide (Glibenclamide) is an ATP-dependent KIR6 and CFTR Cl- channel blocker
10238-21-8 sc-200982
sc-200982A
sc-200982D
sc-200982B
sc-200982C
1 g
5 g
25 g
100 g
500 g
$32.00
$50.00
$100.00
$159.00
$510.00
31
(1)
Neuropeptide Y
Neuropeptide Y is a potassium channel blocker, potent vasoconstrictor and reversible inhibitor of Ca2+-activated K+ channels
90880-35-6 sc-3140
0.5 mg
$91.00
4
(0)
Flupirtine Maleate
Flupirtine Maleate is an indirect NMDA antagonist and Potassium channel activator
75507-68-5 sc-218512
10 mg
$99.00
1
(1)
Paxilline
Paxilline is a selective and reversible calcium-activated potassium channel blocker
57186-25-1 sc-3588
sc-3588A
5 mg
25 mg
$200.00
$409.00
14
(1)
Tetraethylammonium chloride
Tetraethylammonium chloride is a small molecule blocker of K+ channels
56-34-8 sc-202834
25 g
$43.00
2
(1)
Chlorpromazine, Hydrochloride
Chlorpromazine, Hydrochloride is an inhibitor of PDE, D2DR, NOS1, and PLA2
69-09-0 sc-202537
sc-202537A
sc-202537B
sc-202537C
sc-202537D
500 mg
5 g
25 g
100 g
250 g
$32.00
$48.00
$140.00
$480.00
$1,060.00
5
(1)
Apamin
Apamin is a potent and highly selective inhibitor of the low conductance Ca2+-activated K+ channel
24345-16-2 sc-200994
sc-200994A
500 µg
1 mg
$155.00
$265.00
6
(1)
R-(+)-DIOA
R-(+)-DIOA is an inhibitor of the K+/Cl--cotransport that does not affect the bumetanide-Na+/K+/Cl--cotransport system
81166-47-4 sc-203230
sc-203230A
5 mg
25 mg
$154.00
$700.00
2
(0)
ICA 069673
ICA 069673 is a selective activator of the KCNQ2/Q3 potassium channel
582323-16-8 sc-362745
sc-362745A
10 mg
50 mg
$159.00
$645.00
0
(0)
4-Aminopyridine
4-Aminopyridine is a nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane
504-24-5 sc-202421
sc-202421A
sc-202421B
25 g
100 g
1 kg
$36.00
$118.00
$1,110.00
3
(2)
TRAM-34
TRAM-34 is an inhibitor of IKCa1 channels and a cell proliferation modulator
289905-88-0 sc-201005
sc-201005A
5 mg
25 mg
$100.00
$190.00
8
(1)
Astemizole
Astemizole is a potent and selective H1-receptor antagonist that displays antihistamine and antimalarial activity
68844-77-9 sc-201088
sc-201088A
10 mg
50 mg
$69.00
$275.00
2
(1)
5-Hydroxydecanoate sodium salt
5-Hydroxydecanoate sodium salt is an inhibitor of ATP-sensitive K+ channels
71186-53-3 sc-200992
sc-200992A
100 mg
500 mg
$85.00
$325.00
6
(1)
Dronedarone HCl
Dronedarone HCl is a calcium channlel protein inhibitor
141625-93-6 sc-362060
10 mg
$150.00
0
(0)
Tolbutamide
Tolbutamide is a hypoglycemic agonist for secretion of islet hormones
64-77-7 sc-203298
5 g
$35.00
2
(1)
Diazoxide
Diazoxide is a selective ATP-dependent K+ (Kir6) channel activator
364-98-7 sc-200980
1 g
$224.00
4
(1)
1-EBIO
1-EBIO is a potassium channel modulator of epithelial KCa channels
10045-45-1 sc-201695
sc-201695A
10 mg
50 mg
$85.00
$319.00
1
(1)
Pinacidil monohydrate
Pinacidil monohydrate is a K+ channel activator
85371-64-8 sc-203198
sc-203198A
10 mg
50 mg
$35.00
$60.00
4
(1)
(−)-[3R,4S]-Chromanol 293B
(−)-[3R,4S]-Chromanol 293B is a selective inhibitor of the slow component of delayed rectifier K+ current
163163-24-4 sc-361081
sc-361081A
10 mg
50 mg
$189.00
$795.00
0
(0)
BMS 191011
BMS 191011 is an opener of cloned large-conductance, Ca2+-activated potassium channel
202821-81-6 sc-203847
sc-203847A
10 mg
50 mg
$185.00
$750.00
0
(0)
Dequalinium chloride
Dequalinium chloride is a selective blocker of apamin-sensitive K+ channels
522-51-0 sc-214869A
sc-214869
500 mg
5 g
$51.00
$135.00
2
(0)
Quinine hemisulfate
Quinine hemisulfate is a Stereoisomer of quinidine
6119-70-6 sc-202305
10 g
$50.00
0
(0)
Quinidine hydrochloride monohydrate
Quinidine hydrochloride monohydrate is a potassium channel blocker
6151-40-2 sc-215772
sc-215772A
5 g
10 g
$38.00
$69.00
0
(0)
Verruculogen
Verruculogen is a neurotoxin that inhibits the M phase of the mammalian cell cycle
12771-72-1 sc-204939
sc-204939A
1 mg
5 mg
$112.00
$278.00
0
(1)
U-37883A
U-37883A is a potent inhibitor of vascular smooth muscle KIR6 channels
57568-80-6 sc-201001
sc-201001A
5 mg
25 mg
$77.00
$370.00
1
(0)
Docosahexaenoyl Ethanolamide
Docosahexaenoyl Ethanolamide is an ethanolamine amide of DHA
162758-94-3 sc-221563
sc-221563A
5 mg
10 mg
$61.00
$105.00
0
(0)
NS 1643
NS 1643 is an antiarrhythmic activator of hERG K+ channels
448895-37-2 sc-204135
sc-204135A
10 mg
50 mg
$114.00
$450.00
2
(1)
(-)-Bicuculline methiodide
(−)-Bicuculline methiodide is a N-methylated derivative of the GABAA antagonist (+)-bicuculline
40709-69-1 sc-200485
50 mg
$142.00
5
(1)
S-(+)-Niguldipine hydrochloride
S-(+)-Niguldipine hydrochloride is a calcium channel protein inhibitor
113165-32-5 sc-203248
10 mg
$124.00
1
(0)
PCO 400
PCO 400 is an analog of comakalim that acts as a selective and potent ATP-sensitive K+ channel opener
121055-10-5 sc-200989
sc-200989A
20 mg
100 mg
$60.00
$213.00
2
(0)
SK&F 96365
SK&F 96365 is a calcium channel protein and Stim 1 inhibitor
130495-35-1 sc-201475
sc-201475B
sc-201475A
sc-201475C
5 mg
10 mg
25 mg
50 mg
$99.00
$152.00
$381.00
$630.00
1
(1)
AM 92016 hydrochloride
AM 92016 hydrochloride is a specific blocker of the time dependent delayed rectifier potassium current
178894-81-0 sc-203506
sc-203506A
10 mg
50 mg
$225.00
$1,125.00
0
(0)
Aprindine hydrochloride
Aprindine hydrochloride is an hERG channel blocker
33237-74-0 sc-252383
10 mg
$123.00
0
(0)
L-364,373
L-364,373 is an activator of KCNQ1 (KVLQT1) channels
103342-82-1 sc-204036
sc-204036A
2.5 mg
50 mg
$225.00
$915.00
0
(0)
CP 339818 hydrochloride
CP 339818 hydrochloride is a non-peptide and inhibitor of Kv1.3
185855-91-8 sc-203903
sc-203903A
10 mg
50 mg
$155.00
$660.00
0
(0)
UCL 1684 ditrifluoroacetate
UCL 1684 ditrifluoroacetate is a potent, non-peptide blocker of the apamin-sensitive Ca2+-activated K+ channel.
201147-19-5 sc-253818
5 mg
$235.00
1
(0)
Paxillinol
sc-205792
2 mg
$150.00
0
(0)
Tertiapin LQ
Tertiapin LQ is a tertiapin-Q derivative that blocks Kir1.1 channels
sc-362807
1 mg
$175.00
0
(0)
Rutaecarpine
Rutaecarpine is an inhibitor of Cox-2 and platelet aggregation
84-26-4 sc-205846
sc-205846A
10 mg
25 mg
$123.00
$359.00
1
(0)
Doxapram
Doxapram is a central respiratory stimulant
309-29-5 sc-279007
5 mg
$100.00
0
(0)
Adenosine 5prime-Triphosphate, disodium salt
Adenosine 5′-Triphosphate, disodium salt is a p2 purinergicagonist
987-65-5 sc-202040
sc-202040A
1 g
5 g
$31.00
$60.00
9
(1)
Rose Bengal lactone
Rose Bengal lactone is a useful dye
4159-77-7 sc-219991
1 g
$95.00
0
(0)
Isopimaric Acid
Isopimaric Acid is potent Ca-activated K+ channel opener
5835-26-7 sc-269270
5 mg
$69.00
1
(0)
Quinine hydrochloride dihydrate
Quinine hydrochloride dihydrate is a Potassium channel blocker
6119-47-7 sc-212619
sc-212619A
5 g
25 g
$53.00
$170.00
0
(0)
Quinidine sulfate dihydrate
Quinidine sulfate dihydrate is a Na+ channel blocker
6591-63-5 sc-205967
5 g
$60.00
0
(0)
Penitrem A
Penitrem A is a selective and irreversible blocker of the smooth muscle high conductance Ca2+-activated K+ channel
12627-35-9 sc-200997
sc-200997A
1 mg
5 mg
$70.00
$206.00
5
(1)
Tolfenamic Acid
Tolfenamic Acid is a non steroidal anti-inflammatory agent found to inhibit COX-2 isoenzymes
13710-19-5 sc-204918
sc-204918A
5 g
25 g
$68.00
$306.00
0
(1)
BL-1249
BL-1249 is a putative activator of potassium TREK-1 channel
18200-13-0 sc-252498
10 mg
$215.00
0
(1)
Gliclazide
Gliclazide is a hypoglycemic agent
21187-98-4 sc-211561
1 g
$60.00
1
(0)
Glipizide
Glipizide is a hypoglycemic agent that enhances insulin secretion
29094-61-9 sc-204768
sc-204768A
1 g
5 g
$147.00
$600.00
0
(1)
Minoxidil (U-10858)
Minoxidil (U-10858) is a selective ATP dependent K+ (Kir6) channel activator
38304-91-5 sc-200984
sc-200984A
100 mg
1 g
$67.00
$337.00
0
(0)
Cibenzoline
CAS: 53267-01-9, MF: C18H18N2, MW: 262.356, Purity: ≥95%
53267-01-9 sc-268718
10 mg
$200.00
0
(0)
(−)-Bicuculline methochloride
(−)-Bicuculline methochloride is a water-soluble GABAA antagonist
53552-05-9 sc-203528
sc-203528A
sc-203528B
10 mg
50 mg
500 mg
$109.00
$323.00
$5,003.00
0
(0)
P1075
P1075 is a potent KATP (Kir6) channel opener
60559-98-0 sc-203657
sc-203657A
10 mg
50 mg
$205.00
$860.00
1
(1)
Gabapentin-lactam
Gabapentin-lactam is a potassium channel modulator and potential neuroprotector
64744-50-9 sc-201003
sc-201003A
50 mg
250 mg
$64.00
$196.00
0
(0)
Nicorandil
Nicorandil is a small molecule KATP (Kir6) channel opener and NO donor
65141-46-0 sc-200995
sc-200995A
sc-200995B
sc-200995C
50 mg
250 mg
100 mg
1 g
$57.00
$240.00
$98.00
$500.00
4
(1)
Adenylyl-imidodiphosphate Lithium Salt
Adenylyl-imidodiphosphate Lithium Salt is a competitive inhibitor of ATP-dependent enzymes
72957-42-7 sc-203805
25 mg
$290.00
1
(1)
CyPPA
CyPPA is an activator of small conductance Ca2+ activated K+ channels
73029-73-9 sc-205281
sc-205281A
10 mg
50 mg
$145.00
$645.00
0
(0)
α-Dendrotoxin
α-Dendrotoxin is an inducer of acetylcholine release at neuromuscular junction
74504-53-3 sc-252333
0.1 mg
$420.00
0
(1)
Minoxidil sulfate (U-58838)
Minoxidil sulfate (U-58838) is a K+ channel agonist and a strong vascular smooth muscle relaxant
83701-22-8 sc-200987
sc-200987A
sc-200987B
sc-200987C
5 mg
25 mg
50 mg
100 mg
$90.00
$309.00
$480.00
$950.00
0
(0)
(+/-)-Cromakalim
(±)-Cromakalim is a prototypical Kir6 (KATP) channel activator
94470-67-4 sc-217958
25 mg
$325.00
0
(0)
Levcromakalim
Levcromakalim is an active enantiomer of the prototypical KATP(Kir6) channel opener cromakalim
94535-50-9 sc-361230
sc-361230A
10 mg
50 mg
$225.00
$928.00
1
(0)
Charybdotoxin
Charybdotoxin is a potent and selective inhibitor of the large conductance Ca2+-activated K+ channels
95751-30-7 sc-200979
100 µg
$401.00
9
(0)
Linopirdine dihydrochloride
Linopirdine dihydrochloride is a KCNQ (Kv7) blocker
113168-57-3 sc-204058
sc-204058A
10 mg
50 mg
$165.00
$700.00
0
(1)
E-4031 dihydrochloride
E-4031 dihydrochloride is a K+ channel blocker that spawned a class of antiarrhythmic molecules
113559-13-0 sc-203034
5 mg
$154.00
1
(1)
XE 991 dihydrochloride
XE 991 dihydrochloride is a potent & selective inhibitor of KCNQ voltage-gated K-channels
122955-42-4 sc-203453
sc-203453A
10 mg
50 mg
$165.00
$700.00
0
(1)
Y-26763
Y-26763 is a KATP (Kir6) channel opener
127408-31-5 sc-204406
sc-204406A
10 mg
50 mg
$175.00
$709.00
0
(1)
Repaglinide
Repaglinide is a KIR6 (KATP) channel blocker
135062-02-1 sc-219959
sc-219959A
sc-219959B
100 mg
250 mg
1 g
$211.00
$406.00
$1,305.00
2
(0)
UK-78282 monohydrochloride
UK-78282 monohydrochloride is an inhibitor of Kv1.3 and Kv1.4 potassium channels
136647-02-4 sc-253820
5 mg
$119.00
0
(0)
Kaliotoxin
Kaliotoxin is a highly selective, high conductance Ca2+-activated Kv1.1 and Kv1.3 blocker
145199-73-1 sc-362754
10 µg
$98.00
0
(0)
Mitiglinide Calcium
Mitiglinide Calcium is a closer of K+-ATP channels
145375-43-5 sc-204808
sc-204808A
100 mg
250 mg
$168.00
$315.00
0
(0)
ZM 226600
ZM 226600 is a potent Kir6 (KATP) channel opener
147695-92-9 sc-281189
sc-281189A
10 mg
50 mg
$100.00
$348.00
0
(0)
NS-1619
NS-1619 is a selective large conductance calcium activated potassium channel activator
153587-01-0 sc-200986
5 mg
$130.00
2
(1)
LY 303511
LY 303511 is a negative control for PI 3-kinase inhibitors
154447-38-8 sc-202215
sc-202215A
1 mg
5 mg
$65.00
$268.00
3
(1)
Chromanol 293B
Chromanol 293B is a blocker of the slow delayed rectifier K+ current
163163-23-3 sc-203889
sc-203889A
10 mg
50 mg
$170.00
$739.00
1
(1)
UCL-1848 trifluoroacetate salt
201147-53-7 sc-253819
sc-253819A
5 mg
25 mg
$151.00
$500.00
0
(0)
VU 590 dihydrochloride
VU 590 dihydrochloride is an inhibitor of the renal, outer medullary potassium channel, KIR7.1
313505-85-0 sc-358792
sc-358792A
10 mg
50 mg
$109.00
$440.00
0
(0)
CP-339818
CP-339818 is a compound blocking both Kv1.3 and Kv1.4
478341-55-8 sc-252641
5 mg
$62.00
0
(0)
GW 542573X
GW 542573X is a small-conductance Ca2+-activated K+ channel activator
660846-41-3 sc-362741
sc-362741A
10 mg
50 mg
$175.00
$739.00
0
(0)
Psora-4
Psora-4 is a potassium channel modulator
724709-68-6 sc-253325
5 mg
$196.00
0
(0)
5-(4-Phenoxybutoxy)psoralen
5-(4-Phenoxybutoxy)psoralen is a selective inhibitor of Kv1.3, voltage-gated potassium channel
870653-45-5 sc-252247
sc-252247A
5 mg
25 mg
$114.00
$700.00
1
(0)
UCL 2077
UCL 2077 is a slow afterhyperpolarization channel blocker
918311-87-2 sc-204371
sc-204371A
10 mg
50 mg
$135.00
$575.00
0
(0)
Tetraethylammonium bromide
71-91-0 sc-251173
sc-251173A
25 g
250 g
$78.00
$167.00
2
(0)
PD-118057
PD-118057 is an activator of HERG (ether-a-go-go-related (hERG) potassium channel)
313674-97-4 sc-253238
5 mg
$215.00
0
(0)
Potassium dicyanoargentate
CAS: 506-61-6, MF: C2AgKN2, MW: 199.00
506-61-6 sc-253300
10 g
$35.00
0
(0)
N-Salicyloyltryptamine
31384-98-2 sc-253124
5 mg
$88.00
0
(0)
Alinidine
CAS: 33178-86-8, MF: C12H13Cl2N3, MW: 270.16
33178-86-8 sc-252357
sc-252357A
10 mg
100 mg
$98.00
$600.00
0
(0)
YS-035 hydrochloride
YS-035 hydrochloride is a Ca2+ blocker and inhibitor of outward K+ currents
33978-72-2 sc-203722
sc-203722A
10 mg
50 mg
$115.00
$485.00
0
(0)
DPO-1
DPO-1 is a blocker of Kv1.5 channel and IKur ultra rapid delayed rectifier potassium current
43077-30-1 sc-203570
sc-203570A
10 mg
50 mg
$170.00
$715.00
0
(0)
SG 209
SG 209 is a K+-channel opener
83440-03-3 sc-204276
sc-204276A
10 mg
50 mg
$90.00
$395.00
0
(0)
Sematilide monohydrochloride monohydrate
101526-62-9 (non-salt) sc-253550
50 mg
$395.00
0
(0)
(S)-O-Methyl Patulin
(S)-O-Methyl Patulin is a protected patulin
123251-09-2 sc-396452
10 mg
$300.00
0
(0)
Y-27152
Y-27152 is a prodrug of the KATP (Kir6) channel opener Y-26763
127408-30-4 sc-204407
sc-204407A
10 mg
50 mg
$189.00
$796.00
0
(0)
Margatoxin
Margatoxin is a specific blocker of Kv1.3, Kv1.6 channels
145808-47-5 sc-358754
sc-358754A
sc-358754B
sc-358754C
sc-358754D
100 µg
500 µg
1 mg
5 mg
10 mg
$144.00
$480.00
$700.00
$2,500.00
$3,347.00
1
(0)
DMP 543
DMP 543 is a K+ channel blocker and acetylcholine release stimulator
160588-45-4 sc-203926
sc-203926A
10 mg
50 mg
$135.00
$595.00
0
(0)
NS 5806
NS 5806 is an activator of the KV4.3 channel that mediates the transient outward K+ current (Ito)
426834-69-7 sc-362773
sc-362773A
5 mg
25 mg
$123.00
$478.00
0
(0)
Tetracaine hydrochloride
Tetracaine hydrochloride is a calcium channel protein inhibitor
136-47-0 sc-251166
sc-251166A
5 g
25 g
$50.00
$91.00
0
(0)
Agitoxin
Agitoxin is a small polypeptide, 38 amino acid residues, that acts as a potent inhibitor of the Shaker K+ channel
78207-24-6 sc-3582
5 µg
$94.00
0
(0)
Tolbutamide-d9
A labelled Tolbutamide and antidiabetic
1219794-57-6 sc-396112
sc-396112A
2.5 mg
25 mg
$280.00
$2,000.00
0
(0)
Dofetilide-d4
Dofetilide-d4 is a potassium channel blocker
sc-218264
1 mg
$300.00
0
(0)
Flupirtine-d4 Hydrochloride Salt
Flupirtine-d4 Hydrochloride Salt is a labeled flupirtine compound
sc-218513
1 mg
$280.00
0
(0)
Glipizide-d11
Glipizide-d11 is a sulfonylurea hypoglycemic agent
1189426-07-0 sc-280738
1 mg
$250.00
0
(0)
Minoxidil-d10
Minoxidil-d10 is an antihypertensive and antialopecia agent
1020718-66-4 sc-218853
5 mg
$300.00
0
(1)
NS8593 hydrochloride
NS8593 hydrochloride is a calcium channel modulator
875755-24-1 sc-253203
5 mg
$138.00
1
(1)
Sotalol-d6 Hydrochloride
Sotalol-d6 Hydrochloride is A deuterium labeled β-adronergic blocker
1246820-85-8 sc-220127
1 mg
$280.00
1
(0)
Clofilium tosylate
Clofilium tosylate is a K+ channel blocker
92953-10-1 sc-391228
sc-391228A
25 mg
100 mg
$160.00
$715.00
0
(0)
Azimilide Dihydrochloride
149888-94-8 sc-503233
10 mg
$220.00
0
(0)