peropsin Inhibitors
Peropsin inhibitors are chemical compounds that interfere with the function of peropsin, a unique opsin protein found primarily in the retina. Opsins are a group of light-sensitive proteins that play essential roles in photoreception across various species. Peropsin, in particular, is a member of the seven-transmembrane domain G-protein-coupled receptor (GPCR) superfamily and has structural similarities with both visual opsins and retinal pigment epithelium-specific proteins. It is expressed in the retinal pigment epithelium (RPE) and is believed to be involved in detecting changes in light conditions or potentially regulating other proteins involved in light perception. Inhibitors of peropsin function by binding to the active site or interacting allosterically to reduce or block its ability to respond to light or signal changes in light intensity.
Peropsin inhibitors likely target the molecular mechanisms underlying the protein's interaction with retinaldehyde, a chromophore that binds to opsins to allow light detection. By interfering with the peropsin-retinaldehyde interaction, these inhibitors may alter the conformational state of peropsin, rendering it inactive or less responsive to environmental light cues. Studies of peropsin inhibitors contribute to understanding the non-visual functions of opsins, particularly in the broader scope of GPCR-mediated signaling pathways. These inhibitors provide valuable insights into how opsins, especially non-visual ones like peropsin, contribute to light-sensing mechanisms beyond classical photoreception, shedding light on the evolutionary development of opsins across different species. The study of such inhibitors could illuminate previously unexplored aspects of cellular signaling in photoreceptive tissues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may downregulate peropsin by binding to retinoic acid receptors that target the promoter region of the peropsin gene, leading to transcriptional repression. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol could decrease peropsin expression by engaging vitamin D receptors, which may repress transcriptional activity of genes associated with the visual cycle. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate may reduce peropsin expression by inhibiting dihydrofolate reductase, leading to decreased availability of methyl donors required for gene silencing via DNA methylation. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea could inhibit peropsin synthesis indirectly by reducing the pool of deoxyribonucleotide triphosphates, hampering DNA synthesis and consequently gene expression during cell division. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid may decrease peropsin levels by inhibiting histone deacetylase, resulting in hyperacetylation of histones and a more open chromatin configuration that could silence gene expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate could downregulate peropsin by altering DNA methylation and histone acetylation patterns, leading to a condensed chromatin state and transcriptional inhibition of the peropsin gene. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol might decrease transcription of the peropsin gene by activating sirtuins, which are known to deacetylate histones and promote chromatin compaction, leading to gene silencing. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
By inhibiting histone deacetylases, sodium butyrate could lead to an open chromatin structure and the subsequent downregulation of genes, including peropsin, through transcriptional interference. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may downregulate peropsin expression by inhibiting the activation of transcription factors specific to the peropsin gene, thereby reducing its transcriptional initiation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride might inhibit peropsin expression by altering the phosphorylation state of transcription factors or co-regulators involved in the expression of the peropsin gene. | ||||||