PARP-1 Inhibitors

PARP-1 inhibitors belong to a distinctive chemical class that targets an enzyme known as poly (ADP-ribose) polymerase 1, or PARP-1 for short. PARP-1 is a crucial player in the cellular DNA repair process, particularly in repairing single-strand breaks in DNA. These inhibitors are designed to selectively bind and inhibit the activity of PARP-1, thus modulating its function. By blocking the enzymatic activity of PARP-1, these compounds prevent the formation of poly (ADP-ribose) chains, which are involved in DNA repair and cellular homeostasis. The inhibition of PARP-1 can disrupt the DNA repair mechanism, leading to the accumulation of DNA damage and consequent cell death. PARP-1 inhibitors exhibit a unique mechanism of action, exerting their effects by interfering with DNA repair rather than directly targeting DNA itself. This distinct mode of action sets PARP-1 inhibitors apart from other classes of compounds that target DNA damage. Due to their specific interaction with PARP-1, these inhibitors have gained considerable attention in various fields of research and hold promise for applications in diverse areas of biology.