NF-E2 p18 Inhibitors
NF-E2 p18 inhibitors encompass a diverse range of chemicals that intricately modulate the activity of the nuclear factor erythroid-derived 2-like 2 (NRF2) and nuclear factor-kappa B (NF-κB) signaling pathways, ultimately impacting the expression and function of NF-E2 p18. ML385, Brusatol, and KEAP1 Inhibitor (KL1333) operate through NRF2 modulation, inhibiting or activating key players in the NRF2-KEAP1 pathway. ML385 and Brusatol suppress NRF2, leading to the disruption of the NRF2-KEAP1 complex, while KL1333 activates NRF2 by inhibiting KEAP1, the negative regulator of NRF2. In addition to NRF2 modulation, Piperlongumine induces reactive oxygen species (ROS) production, influencing both NRF2 and NF-E2 p18. This dual action can perturb cellular redox balance, impacting NF-E2 p18 expression and function. Compounds like BAY 11-7082, Sanguinarine, Curcumin, Auranofin, Withaferin A, Tanshinone IIA, and CDDO-Im primarily target the NF-κB signaling pathway, inhibiting NF-κB activation. This inhibition indirectly intersects with NF-E2 p18-mediated processes, contributing to the modulation of NF-E2 p18 function in specific cellular contexts.
Notably, DMF, a known immunomodulatory compound, activates NRF2, thereby modulating the NRF2-KEAP1 pathway and influencing NF-E2 p18. The dual regulatory roles of these inhibitors highlight the complexity of the cellular mechanisms involved in NF-E2 p18 expression and function. Researchers exploring these inhibitors gain valuable insights into potential strategies for regulating NF-E2 p18 in diverse cellular contexts, providing a foundation for further investigation into the intricate network of redox and inflammatory signaling pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brusatol | 14907-98-3 | sc-507427 | 5 mg | $148.00 | 1 | |
Brusatol is a natural product that inhibits NRF2, the master regulator of antioxidant response. Through NRF2 inhibition, Brusatol indirectly modulates the NRF2-KEAP1 pathway, influencing NF-E2 p18 expression and function. The disruption of NRF2-mediated regulation contributes to the inhibition of NF-E2 p18 in specific cellular contexts. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine is a natural product that induces ROS production and inhibits NRF2. Through ROS induction and NRF2 inhibition, Piperlongumine indirectly modulates the NRF2-KEAP1 pathway, influencing NF-E2 p18 expression and function. The disruption of NRF2-mediated regulation and ROS induction contribute to the inhibition of NF-E2 p18 in specific cellular contexts. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 is an inhibitor of NF-κB activation, affecting the NF-κB signaling pathway. By inhibiting NF-κB activation, BAY 11-7082 indirectly modulates cellular processes related to inflammation, potentially intersecting with NF-E2 p18-mediated processes. The inhibition of NF-κB signaling contributes to the modulation of NF-E2 p18 function in specific cellular contexts. | ||||||
Sanguinarium | 2447-54-3 | sc-473396 | 10 mg | $220.00 | ||
Sanguinarium is a natural alkaloid with anti-inflammatory properties. It inhibits NF-κB activation, indirectly modulating the NF-κB signaling pathway. Through NF-κB inhibition, Sanguinarium potentially intersects with NF-E2 p18-mediated processes, contributing to the modulation of NF-E2 p18 function in specific cellular contexts. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a natural polyphenol with anti-inflammatory properties. It inhibits NF-κB activation, indirectly modulating the NF-κB signaling pathway. Through NF-κB inhibition, Curcumin potentially intersects with NF-E2 p18-mediated processes, contributing to the modulation of NF-E2 p18 function in specific cellular contexts. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin is a gold-containing compound with anti-inflammatory properties. It inhibits NF-κB activation, indirectly modulating the NF-κB signaling pathway. Through NF-κB inhibition, Auranofin potentially intersects with NF-E2 p18-mediated processes, contributing to the modulation of NF-E2 p18 function in specific cellular contexts. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A is a steroidal lactone that inhibits NF-κB activation, indirectly modulating the NF-κB signaling pathway. Through NF-κB inhibition, Withaferin A potentially intersects with NF-E2 p18-mediated processes, contributing to the modulation of NF-E2 p18 function in specific cellular contexts. | ||||||
Tanshinone IIA | 568-72-9 | sc-200932 sc-200932A | 5 mg 25 mg | $88.00 $316.00 | 22 | |
Tanshinone IIA is a natural compound that inhibits NF-κB activation, indirectly modulating the NF-κB signaling pathway. Through NF-κB inhibition, Tanshinone IIA potentially intersects with NF-E2 p18-mediated processes, contributing to the modulation of NF-E2 p18 function in specific cellular contexts. | ||||||
CDDO Imidazolide | 443104-02-7 | sc-504719 | 1 mg | $700.00 | ||
CDDO-Im is a synthetic triterpenoid that activates NRF2 and inhibits NF-κB. Through NRF2 activation and NF-κB inhibition, CDDO-Im modulates the NRF2-KEAP1 and NF-κB signaling pathways, influencing NF-E2 p18 expression and function. The dual modulation contributes to the inhibition of NF-E2 p18 in specific cellular contexts. | ||||||