nephrin Activators
Common nephrin Activators include, but are not limited to Suberoylanilide Hydroxamic Acid CAS 149647-78-9, Retinoic Acid, all trans CAS 302-79-4, β-Estradiol CAS 50-28-2, Curcumin CAS 458-37-7 and 1,1-Dimethylbiguanide, Hydrochloride CAS 1115-70-4.
Nephrin Activators constitute a specific subset of chemical compounds known for their capacity to modulate the activity of nephrin, a key protein involved in maintaining the integrity of the glomerular filtration barrier in the kidneys. This chemical class functions by interacting with and enhancing the signaling pathways associated with nephrin, which is a vital component of the slit diaphragm structure that regulates the passage of substances through the renal filtration process. Nephrin plays a crucial role in preventing the leakage of proteins into the urine and maintaining overall renal function.
Nephrin Activators exert their influence through specific molecular interactions that could amplify the downstream effects of nephrin-mediated signaling, contributing to the fine-tuning of renal filtration, cellular adhesion, and the maintenance of kidney function. The intricate mechanisms through which Nephrin Activators impact nephrin-related pathways remain an area of ongoing scientific exploration, offering insights into the complex interplay between cell-cell interactions, barrier function, and kidney health. The specific ways in which this chemical class engages with nephrin highlight its significance in unraveling the intricacies of renal physiology and enhancing our understanding across various scientific domains.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid (SAHA) is an HDAC inhibitor that can alter chromatin structure, potentially influencing gene expression including nephrin. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
All-trans retinoic acid (ATRA) is a derivative of vitamin A that has been suggested to induce nephrin expression in certain kidney cell models. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estradiol is a natural estrogen and an example of an estrogen receptor agonist that might influence nephrin expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a natural polyphenol found in red grapes, has shown potential to upregulate nephrin expression in certain experimental models. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a compound found in turmeric, has been explored for its potential to increase nephrin expression and protect podocyte function. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
1,1-Dimethylbiguanide, Hydrochloride is an example of a compound that activates AMPK, potentially affecting cellular metabolism and gene expression. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
Tauroursodeoxycholic acid (TUDCA) is a compound that can mitigate endoplasmic reticulum stress and influence gene expression. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $109.00 | 3 | |
Spironolactone is an example of a compound that can modulate the activity of transcription factors such as Sp1, which are involved in nephrin regulation. | ||||||