MFT Activators
Mitochondrial Folate Transporter Activators involves understanding their influence on cellular and mitochondrial metabolism. These compounds interact with a variety of metabolic and signaling pathways that converge on mitochondrial function and the cellular demand for folate. For instance, agents like methotrexate and aminopterin exert their effect by inhibiting the enzyme dihydrofolate reductase, which increases the cellular demand for folate and could upregulate the expression or activity of folate transporters, such as SLC25A32, to restore folate metabolism homeostasis.
On the other hand, compounds like rotenone and antimycin A target the mitochondrial electron transport chain, altering mitochondrial membrane potential and cellular energy status. These disruptions can lead to compensatory metabolic changes, including the modulation of folate transporter activity as part of the cell's adaptive response. Furthermore, metabolic modulators like AICAR, resveratrol, spermidine, NMN, and alpha-ketoglutarate can exert their effects by influencing cellular energy balance, autophagy, and mitochondrial biogenesis or function, which in turn may affect the expression and function of mitochondrial folate transporters. These compounds do not directly activate SLC25A32, but by affecting the metabolic landscape in which this transporter operates, they indirectly promote its functional role in cellular metabolism.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
SAMe is a major methyl donor in the cell and may upregulate folate-dependent methylation reactions, indirectly enhancing the activity of MFT to supply necessary folates. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $30.00 $40.00 $55.00 $160.00 $330.00 $580.00 | 2 | |
Betaine donates methyl groups via the methionine cycle, and its supplementation can increase the demand for folate-mediated one-carbon metabolism, which may drive the activity of MFT. | ||||||
Vitamin B12 | 68-19-9 | sc-296695 sc-296695A sc-296695B sc-296695C sc-296695D sc-296695E | 100 mg 1 g 5 g 25 g 100 g 1 kg | $39.00 $55.00 $204.00 $877.00 $3414.00 $9180.00 | 2 | |
Essential for methionine synthase in the methionine cycle, cobalamin deficiency can lead to folate trapping and a compensatory increase in MFT activity to restore folate homeostasis. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $102.00 | ||
As a cofactor for serine hydroxymethyltransferase, this form of vitamin B6 can enhance the conversion of serine to glycine, generating 5,10-methylene-THF and possibly upregulating MFT to meet the folate demand. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $40.00 $110.00 $515.00 | 3 | |
FAD, a riboflavin-derived cofactor, is necessary for MTHFR which regenerates 5-methyl-THF from 5,10-methylene-THF, potentially increasing the need for MFT activity. | ||||||
Creatine, anhydrous | 57-00-1 | sc-214774 sc-214774A | 10 mg 50 g | $27.00 $77.00 | 2 | |
Creatine synthesis is a major consumer of S-adenosylmethionine-derived methyl groups, and high demand for creatine may increase the need for MFT function. | ||||||
Folinic Acid | 58-05-9 | sc-337846A sc-337846B sc-337846 | 5 mg 25 mg 100 mg | $110.00 $291.00 $592.00 | ||
While often considered a bypass for folate metabolism blocks, its cellular uptake may signal a need for increased mitochondrial folate transport via MFT. | ||||||
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
Elevated homocysteine can indicate impaired methylation reactions and may trigger a compensatory increase in folate transport via MFT to support remethylation. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is a cofactor for several enzymes in folate metabolism, and its presence can optimize enzyme function, potentially enhancing the need for mitochondrial folate import via MFT. | ||||||