Date published: 2026-2-14

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MAGE-3 Activators

Chemical activators of MAGE-3 can engage in a diverse array of biochemical pathways to facilitate the protein's activation. Dibutyryl-cAMP, a cAMP analog, permeates cellular membranes and can activate protein kinase A (PKA). Once activated, PKA can directly phosphorylate MAGE-3, thereby enhancing its functional activity. Similarly, Forskolin, by elevating intracellular cAMP levels, indirectly leads to the activation of PKA, which in turn can phosphorylate and activate MAGE-3. Phorbol 12-myristate 13-acetate (PMA) is known to robustly activate protein kinase C (PKC), which is another kinase that can phosphorylate MAGE-3, leading to its activation. Ionomycin, through its capacity to increase intracellular calcium levels, can activate calcium-dependent protein kinases that may target and phosphorylate MAGE-3. Okadaic Acid, by inhibiting protein phosphatases, can prolong the phosphorylated state of MAGE-3, effectively sustaining its active form.

Further along the spectrum of chemical activators, Epidermal Growth Factor (EGF) stimulates its receptor, initiating a cascade that can result in the activation of kinases that target MAGE-3. Anisomycin, recognized for its role in activating stress-activated protein kinases, can also contribute to the phosphorylation and subsequent activation of MAGE-3. Calyculin A, like Okadaic Acid, inhibits phosphatases, which are enzymes that remove phosphate groups from proteins, thereby potentially maintaining MAGE-3 in an activated state due to sustained phosphorylation. Thapsigargin disrupts calcium homeostasis and can activate kinases that phosphorylate MAGE-3. Bryostatin 1, through its activation of PKC, can lead to the phosphorylation and activation of MAGE-3. Oleoyl-2-acetyl-sn-glycerol, functioning as a diacylglycerol analog, activates PKC, which then can phosphorylate and activate MAGE-3. Lastly, Endothelin-1, by activating its receptors, can stimulate PKC, which subsequently may lead to the phosphorylation and activation of MAGE-3. Each of these chemicals has a distinct mechanism of action, but all converge on the common endpoint of increasing the phosphorylation state of MAGE-3, thereby enhancing its activation state.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Dibutyryl-cAMP

16980-89-5sc-201567
sc-201567A
sc-201567B
sc-201567C
20 mg
100 mg
500 mg
10 g
$47.00
$136.00
$492.00
$4552.00
74
(7)

Dibutyryl-cAMP, a cell-permeable cAMP analog, can activate PKA which then phosphorylates substrates including MAGE-3.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$41.00
$132.00
$214.00
$500.00
$948.00
119
(6)

PMA activates PKC which may lead to the phosphorylation and activation of MAGE-3.

Ionomycin

56092-82-1sc-3592
sc-3592A
1 mg
5 mg
$78.00
$270.00
80
(4)

Ionomycin increases intracellular calcium and activates calcium-dependent kinases that can phosphorylate MAGE-3.

Okadaic Acid

78111-17-8sc-3513
sc-3513A
sc-3513B
25 µg
100 µg
1 mg
$291.00
$530.00
$1800.00
78
(4)

Okadaic Acid inhibits phosphatases, potentially maintaining MAGE-3 in a phosphorylated and active state.

Anisomycin

22862-76-6sc-3524
sc-3524A
5 mg
50 mg
$99.00
$259.00
36
(2)

Anisomycin activates stress-activated protein kinases that may lead to phosphorylation and activation of MAGE-3.

Calyculin A

101932-71-2sc-24000
sc-24000A
10 µg
100 µg
$163.00
$800.00
59
(3)

Calyculin A inhibits phosphatases, which could result in the phosphorylation and activation of MAGE-3.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$136.00
$446.00
114
(2)

Thapsigargin disrupts calcium homeostasis, leading to kinase activation that could phosphorylate MAGE-3.

Bryostatin 1

83314-01-6sc-201407
10 µg
$245.00
9
(1)

Bryostatin 1 activates PKC, possibly leading to phosphorylation and activation of MAGE-3.

1-Oleoyl-2-acetyl-sn-glycerol (OAG)

86390-77-4sc-200417
sc-200417A
10 mg
50 mg
$119.00
$453.00
1
(1)

This DAG analog activates PKC which may lead to phosphorylation and activation of MAGE-3.