Latrophilin-1 Activators
Latrophilin-1 (LPHN1) is a member of the adhesion G protein-coupled receptor (GPCR) family, characterized by a long N-terminal extracellular domain with various protein-protein interaction motifs. This protein is predominantly expressed in the central nervous system and plays a significant role in brain development and synaptic function.
The structure of LPHN1 includes a GPCR autoproteolysis-inducing (GAIN) domain, which suggests that it undergoes autoproteolytic cleavage, a feature unique to adhesion GPCRs. This cleavage is thought to be essential for its function, although the protein remains non-covalently associated after this process. LPHN1 is known for its interaction with α-latrotoxin, a component of black widow spider venom, which binds to it and induces massive neurotransmitter release, leading to toxic effects.Beyond its interaction with α-latrotoxin, LPHN1 is implicated in the regulation of synaptic connectivity and plasticity. It influences neurite outgrowth and may play a role in the formation of neural circuits during development. The receptor is also thought to mediate cell adhesion processes, which are crucial for the correct wiring of neuronal networks.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can modulate gene expression by activating retinoic acid receptors, potentially influencing LPHN1 expression in neural tissue. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
By increasing intracellular cAMP, forskolin can activate PKA, leading to changes in gene transcription, which may include LPHN1. | ||||||
Calcium dibutyryladenosine cyclophosphate | 362-74-3 | sc-482205 | 25 mg | $147.00 | ||
A cAMP analog that can permeate cell membranes and mimic cAMP's role as a second messenger, potentially affecting LPHN1 expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) and can modulate transcription factors, possibly influencing LPHN1 expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium can influence several signaling pathways, including those involved in neural development, potentially affecting LPHN1 expression. | ||||||
Wnt Agonist | 853220-52-7 | sc-222416 sc-222416A | 5 mg 25 mg | $157.00 $609.00 | 23 | |
Activation of Wnt signaling is crucial in neural development and may regulate the expression of genes like LPHN1. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
By increasing intracellular calcium levels, this compound can activate calcium-dependent signaling pathways, potentially influencing LPHN1 expression. | ||||||