IRF-2 Activators
The class of chemicals identified as IRF-2 activators consists of compounds that indirectly influence the pathways and processes associated with IRF-2 activity. These activators do not directly interact with IRF-2 but rather modulate the cellular and molecular context within which IRF-2 operates, leading to changes in its activation or expression. The primary mechanisms employed by these activators include the modulation of signaling pathways, transcriptional regulation, and cellular metabolism. Compounds like Forskolin and Sildenafil citrate, through the elevation of cAMP and cGMP levels respectively, can influence a variety of cellular processes, impacting IRF-2 activity. Polyphenols like EGCG and Resveratrol, and flavonoids like Quercetin, are known to affect multiple signaling pathways, which could lead to the activation of IRF-2 by altering the cellular signaling environment.
Another aspect of these activators is their role in modulating gene expression through receptor-mediated pathways or epigenetic modifications. Retinoic acid and Vitamin D3, through their respective receptors, activate IRF-2 by influencing genes and pathways that interact with or regulate IRF-2. Similarly, compounds like Sodium butyrate, by altering chromatin structure, can influence the transcription of genes involved in the regulation or activity of IRF-2. It is crucial to note that the effects of these compounds are not specific to IRF-2 and can impact a wide range of cellular functions. Therefore, their ability to specifically activate IRF-2 requires careful experimental validation, considering the broader cellular effects and the specific context of IRF-2 expression and function. The effectiveness of these compounds in activating IRF-2 depends on various factors, including cellular context, expression levels of IRF-2, and the presence of other interacting proteins and signaling molecules.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels. Elevated cAMP can modulate various signaling pathways, potentially leading to the activation of transcription factors like IRF-2 by influencing their expression or activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a polyphenol found in green tea, has been shown to modulate multiple signaling pathways. It can influence the activity of transcription factors, possibly including IRF-2, by altering the cellular signaling environment. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol affects various signaling pathways, including those related to cell survival and inflammation. It can indirectly activate IRF-2 by modulating pathways that control its activity or expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, regulates gene expression through retinoic acid receptors. It can potentially activate IRF-2 by influencing genes and pathways that interact with or regulate IRF-2. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride influences the Wnt/β-catenin pathway, which can interact with various transcription factors. Through this pathway modulation, lithium chloride could indirectly activate IRF-2. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol, through its active metabolite, modulates gene expression via the vitamin D receptor. This can lead to the activation of IRF-2 by influencing related genes and signaling pathways. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone, a PPARγ agonist, modulates lipid metabolism and insulin sensitivity. Its influence on gene expression can indirectly activate IRF-2 by altering pathways associated with IRF-2 activity. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin, primarily used for diabetes management, influences AMPK signaling. This can lead to indirect activation of IRF-2 by affecting cellular energy status and related signaling pathways. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, a histone deacetylase inhibitor, influences gene expression by affecting chromatin structure. It can indirectly activate IRF-2 by modulating the transcription of genes that regulate or are regulated by IRF-2. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, modulates various signaling pathways and affects gene expression. It can indirectly activate IRF-2 by influencing the cellular signaling milieu, possibly affecting pathways involving IRF-2. | ||||||