IP3R-III Activators
The IP3R-II activators comprise a diverse set of compounds that directly or indirectly influence the activity of IP3R-II, a critical player in intracellular calcium signaling. Notably, substances like 2-APB and Xestospongin C act as IP3 receptor antagonists, with 2-APB inhibiting IP3 binding and Xestospongin C specifically targeting IP3R-II. These compounds modulate the release of calcium from intracellular stores, impacting cellular processes regulated by intracellular calcium signaling. On the other hand, compounds such as 8-Bromo-cADPR and Ruthenium Red showcase indirect modulation of IP3R-II. 8-Bromo-cADPR enhances the sensitivity of IP3R-II to IP3, leading to increased calcium release. In contrast, Ruthenium Red, a non-specific IP3 receptor inhibitor, blocks calcium release from intracellular stores. These compounds collectively highlight the intricate regulatory mechanisms involved in IP3R-II activation and its role in calcium signaling. Additionally, modulators like U73122 and Carbachol influence IP3R-II indirectly through pathways involving phospholipase C (PLC) activation. U73122 inhibits PLC, reducing IP3 levels and subsequently affecting IP3R-II activation. Carbachol, through muscarinic acetylcholine receptor activation, triggers PLC-mediated IP3 production, leading to altered calcium release from intracellular stores.
Other compounds like ATP and Miconazole showcase the influence of purinergic receptors and inositol monophosphatase inhibition, respectively, on IP3R-II activity. ATP, through purinergic receptors, activates PLC and increases IP3 production, ultimately affecting IP3R-II activation. Miconazole, by blocking inositol monophosphatase, reduces IP3 availability, impacting IP3R-II activation and calcium release. BAPTA-AM and Procaine, as calcium chelator and PLC inhibitor, respectively, directly or indirectly modulate IP3R-II activity. BAPTA-AM sequesters intracellular calcium, altering IP3R-II activation and downstream signaling. Procaine, through PLC inhibition, decreases IP3 levels, influencing IP3R-II activity and calcium release.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
8-Bromo-cADP-Ribose (8-Br-cADPR) | 151898-26-9 | sc-201514 sc-201514B | 100 µg 1 mg | $130.00 $550.00 | 12 | |
8-Bromo-cADPR acts as a modulator of IP3R-II by enhancing its sensitivity to IP3. It augments the interaction between IP3 and IP3R-II, leading to increased calcium release from the endoplasmic reticulum. This influences cellular processes regulated by intracellular calcium signaling. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Ruthenium Red is a non-specific inhibitor of IP3 receptors, including IP3R-II. By binding to IP3R-II, it blocks the calcium release from intracellular stores, influencing cellular processes regulated by intracellular calcium signaling. Ruthenium Red is known for its inhibitory effect on IP3R-II activity. | ||||||
Carbachol | 51-83-2 | sc-202092 sc-202092A sc-202092C sc-202092D sc-202092B sc-202092E | 1 g 10 g 25 g 50 g 100 g 250 g | $120.00 $275.00 $380.00 $670.00 $1400.00 $3000.00 | 12 | |
Carbachol influences IP3R-II indirectly by activating muscarinic acetylcholine receptors. The downstream signaling cascade involves PLC activation, leading to increased IP3 production. This, in turn, enhances IP3R-II activation, resulting in elevated calcium release from intracellular stores and modulating cellular processes regulated by calcium signaling. | ||||||
ATP | 56-65-5 | sc-507511 | 5 g | $17.00 | ||
Adenosine 5'-Triphosphate, disodium salt modulates IP3R-II indirectly through purinergic receptors. Binding of ATP to purinergic receptors activates PLC, leading to increased IP3 production. Subsequently, IP3R-II is activated, resulting in enhanced calcium release from intracellular stores and influencing cellular processes regulated by intracellular calcium signaling. | ||||||
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $65.00 $157.00 | 2 | |
Miconazole indirectly influences IP3R-II through its inhibition of inositol monophosphatase. By blocking inositol monophosphatase, it reduces the availability of inositol for IP3 production. This leads to decreased IP3 levels, subsequently affecting IP3R-II activation and modulating cellular processes regulated by intracellular calcium signaling. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM is a membrane-permeable calcium chelator. By sequestering intracellular calcium, it indirectly modulates IP3R-II activity. Reduction in intracellular calcium levels influences IP3R-II activation, leading to alterations in cellular processes regulated by intracellular calcium signaling. | ||||||
Procaine | 59-46-1 | sc-296134 sc-296134A sc-296134B sc-296134C | 25 g 50 g 500 g 1 kg | $108.00 $189.00 $399.00 $616.00 | 1 | |
Procaine modulates IP3R-II indirectly through its inhibitory effect on IP3 production. By inhibiting PLC, it decreases the synthesis of IP3, leading to reduced activation of IP3R-II. This results in lowered calcium release from intracellular stores, influencing cellular processes regulated by intracellular calcium signaling. | ||||||