Santa Cruz Biotechnology offers a variety of gene silencing products to target growth factors and hormones via RNA interference (RNAi). Ephrins, which act as ligands for Eph receptors, are cell-surface proteins which fall into two categories, ephrin-A and ephrin-B, based on their structure and function. Eph receptors and ephrins exhibit complementary expression in many tissues during embryogenesis indicating that bidirectional activation of Eph receptors and ephrin-B proteins may occur at expression domain interfaces. Mouse, rat, human and Xenopus laevis ephrin-B1 are phosphorylated on Tyr 317 in vivo, which may be induced by a receptor tyrosine kinase. A total of three members of the transforming growth factor beta (TGFβ) family, TGFβ1, TGFβ2 and TGFβ3, have been identified in mammals. To knockdown expression of growth factors and hormones, Santa Cruz Biotechnology offers siRNA, shRNA plasmid and shRNA lentiviral particles.
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