Gm648 Activators
The class of cancer/testis antigen 45 Activators comprises compounds that influence various biochemical and cellular pathways, resulting in the upregulation of this protein's activity. Forskolin, by raising cAMP levels, leads to PKA activation which can phosphorylate proteins that potentially regulate cancer/testis antigen 45. PMA, through PKC activation, might alter the phosphorylation status of proteins that interact with cancer/testis antigen 45, thereby enhancing its function. Ionomycin, by increasing intracellular calcium, could activate pathways that indirectly increase the functional activity of cancer/testis antigen 45. EGCG may induce hypomethylation of DNA, potentially leading to the expression of proteins that interact with cancer/testis antigen 45 and enhance its activity.
Retinoic acid and sodium butyrate, by modulating gene expression and influencing chromatin structure respectively, may lead to the expression of proteins thatinteract with or regulate cancer/testis antigen 45. Lithium chloride, as a GSK-3 inhibitor, may prevent the phosphorylation of proteins that interact with cancer/testis antigen 45, enhancing its function. Resveratrol activates SIRT1, potentially modifying the activity of proteins that regulate cancer/testis antigen 45. Curcumin's inhibition of NF-κB might change the cellular environment in a way that upregulates proteins associated with cancer/testis antigen 45, increasing its activity. Sildenafil and dibutyryl cAMP both act by inhibiting the breakdown of cyclic nucleotides or acting as a cyclic nucleotide analog, respectively, leading to PKA activation, which may influence the activity of cancer/testis antigen 45. Hydroxychloroquine, by increasing lysosomal pH, could modify the degradation of proteins that regulate the function of cancer/testis antigen 45.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, which increases cyclic AMP (cAMP) levels in cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate various proteins that may interact with or regulate cancer/testis antigen 45, leading to its functional enhancement. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in numerous signaling pathways. PKC activation can lead to changes in protein phosphorylation and function, including proteins that may form complexes with or modulate the activity of cancer/testis antigen 45. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent signaling pathways. This increase in calcium may enhance the activity of proteins that regulate cancer/testis antigen 45 function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a polyphenol found in green tea, inhibits DNA methyltransferases, which can lead to DNA demethylation and the subsequent activation of genes encoding proteins that interact with or regulate cancer/testis antigen 45. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid modulates gene expression by activating retinoic acid receptors. Activation of these receptors can lead to upregulation of genes whose products are involved in the same cellular processes as cancer/testis antigen 45, potentially enhancing its function. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that leads to hyperacetylation of histones, resulting in a more open chromatin structure and active gene transcription. This can induce the expression of genes coding for proteins that enhance the function of cancer/testis antigen 45. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium, a glycogen synthase kinase-3 (GSK-3) inhibitor, prevents the phosphorylation and inactivation of GSK-3 substrates, which may include proteins that regulate the function of cancer/testis antigen 45. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuin 1 (SIRT1), a protein deacetylase. Through deacetylation, SIRT1 can enhance the activity of certain transcription factors or other proteins that control the expression of factors interacting with cancer/testis antigen 45. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit NF-κB, a transcription factor that regulates the expression of various genes. Inhibition of NF-κB can lead to changes in the cellular environment that enhance the activity of proteins that are in the same pathway or regulate cancer/testis antigen 45. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $56.00 | 1 | |
Hydroxychloroquine can increase lysosomal pH, which may affect the degradation and recycling of cellular components. This alteration in lysosomal function can influence the activity of proteins that modulate cancer/testis antigen 45 function. | ||||||