Santa Cruz Biotechnology offers a variety of gene editing products to target homeodomain proteins using the CRISPR/Cas9 system. Homeodomain proteins bind DNA in a specific manner, though the specificity of one homeodomain protein is not usually enough to recognize its desired target genes only. To solve this problem, homeodomain proteins normally function in the promoter region of their target genes and complex with other transcription factors, which are often other homeodomain proteins. These complexes have a much higher target specificity than a single homeodomain protein. To knockdown expression of homeodomain proteins, Santa Cruz Biotechnology offers target-specific CRISPR/Cas9 Knockout (KO) Plasmids and CRISPR Double Nickase Plasmids.To activate transcription of homeodomain protein genes, Santa Cruz Biotechnology offers target-specific CRISPR/dCas9 Activation Plasmids and CRISPR Lenti Activation Systems.