GADD 45 Activators

GADD45 Activators encompass a diverse array of chemical compounds that indirectly enhance the functional activity of GADD45 through various specific signaling pathways or biological processes. Spermine, curcumin, resveratrol, sulforaphane, and vitamin D3 all serve as activators of GADD45 by influencing distinct pathways that converge on the stress response and DNA repair mechanisms, which are central to GADD45's role. Spermine, by altering ROS levels, and curcumin, through modulation of the NF-κB pathway, both potentiate GADD45's involvement in managing cellular stress. Resveratrol's activation of SIRT1 and sulforaphane's impact on the Keap1-Nrf2 pathway further enable GADD45 to execute its function in DNA damage response and cell cycle regulation. Vitamin D3 operates through the VDR pathway, reinforcing GADD45's engagement in DNA repair processes.

Additionally, zinc ions, arsenic trioxide, quercetin, EGCG, melatonin, omega-3 fatty acids, and lithium are all implicated in the activation of GADD45 by targeting various cellular processes that GADD45 is directly involved in.