FGF-10 Activators
FGF-10 Activators belong to a chemical class of compounds involved in the regulation of Fibroblast Growth Factor 10 (FGF-10), a member of the fibroblast growth factor (FGF) family of proteins. FGF-10 is a paracrine growth factor that plays a pivotal role in various developmental processes and tissue homeostasis, particularly in the development of epithelial organs and tissues. During embryonic development, FGF-10 signaling is essential for the formation and branching of several organs, including the lungs, mammary glands, salivary glands, and skin. It acts as a key regulator of epithelial-mesenchymal interactions, where it stimulates the proliferation, migration, and differentiation of epithelial cells, as well as the growth and development of surrounding mesenchymal tissues.
The mechanism of action of FGF-10 Activators typically involves their interaction with FGF-10, influencing its binding affinity for its cognate receptors (FGFR2b) or modulating downstream signaling pathways. By modulating FGF-10 activity, these activators impact organ development, tissue repair, and regeneration processes that involve FGF-10-mediated signaling. Research into FGF-10 Activators provides valuable insights into the complex regulatory mechanisms governing organogenesis and tissue morphogenesis during embryonic development and beyond. Understanding how these activators interact with FGF-10 contributes to our knowledge of the intricate processes involved in tissue development and maintenance.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a synthetic glucocorticoid that regulates various genes through binding to glucocorticoid receptors. As a critical factor in lung branching morphogenesis, FGF-10 expression could potentially be increased by dexamethasone through transcriptional mechanisms involving receptor crosstalk and signaling networks. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a derivative of vitamin A, regulates expression of genes involved in embryonic development and cell differentiation. FGF-10 plays important roles in these processes, thus retinoic acid may transactivate specific enhancers to boost FGF-10 transcription during organogenesis. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A is an endocrine disruptor that mimics estrogen. FGF-10 expression in certain tissues is hormone-responsive and may thus increase following bisphenol A interactions with estrogen receptors during critical embryonic windows of lung development and branching. | ||||||
Di-n-butyl phthalate | 84-74-2 | sc-257307 sc-257307A sc-257307B | 5 g 25 g 1 kg | $40.00 $51.00 $102.00 | 1 | |
Di-n-butyl phthalate is a high production volume chemical commonly used as a plasticizer. It too has estrogenic activity that could affect FGF-10 levels through receptor-mediated transcriptional or post-transcriptional changes important for regulating morphogenesis. | ||||||