DHCR24 Inhibitors

DHCR24 inhibitors are a class of chemical compounds that target and inhibit the enzyme DHCR24, also known as 3β-hydroxysterol Δ24-reductase. This enzyme plays a crucial role in the biosynthesis of cholesterol and other sterols in the human body. Cholesterol is an essential lipid molecule that serves as a structural component of cell membranes and plays a pivotal role in various physiological processes. DHCR24 inhibitors interfere with the enzymatic activity of DHCR24, disrupting the cholesterol biosynthesis pathway at a specific step. By doing so, these inhibitors can modulate cholesterol levels in cells and tissues.The inhibition of DHCR24 by these compounds can have wide-ranging effects on cellular function. Since cholesterol is a fundamental component of cell membranes, its levels influence membrane fluidity and permeability, which can impact cell signaling, transport processes, and overall cell health. Additionally, cholesterol is a precursor for the synthesis of various bioactive molecules, including steroid hormones and bile acids.