DC-SIGNR Activators

The chemical class known as DC-SIGNR Activators comprises a range of compounds that directly or indirectly enhance the functional activity of DC-SIGNR. Fucose, a specific ligand for DC-SIGNR, directly engages with the protein, leading to increased binding and activation of downstream signaling events, ultimately enhancing DC-SIGNR activity in the context of immune responses. Mannan, acting as a mimetic of pathogen-associated molecular patterns (PAMPs), activates DC-SIGNR by initiating signaling cascades that enhance the functional activity of the protein, particularly in the recognition of pathogens. Curdlan directly activates DC-SIGNR by engaging with its C-type lectin domain, triggering immune responses and cellular activation.

Poly(I:C), an indirect activator, simulates viral double-stranded RNA, leading to the activation of DC-SIGNR and subsequent immune responses against viral pathogens. β-Glucan and Zymosan, resembling fungal cell wall components, indirectly activate DC-SIGNR, modulating immune responses against fungal pathogens. Laminarin, resembling β-glucan structures, serves as an indirect activator, enhancing DC-SIGNR activity in the context of immune responses against fungal challenges. Glucuronic Acid, O-Methylmannose, N-Acetylglucosamine, and Maltose, as specific ligands for DC-SIGNR, directly enhance its activity by increasing binding and activating downstream signaling events, leading to immune responses and cellular processes associated with DC-SIGNR function. This chemical class provides a diverse set of compounds that can be utilized to enhance DC-SIGNR activity through specific pathways and biological processes.