CCT B Activators

CCT B," often referred to as "CCT2" or "TCP1 beta," is a protein encoded by the CCT2 gene in humans. It is a subunit of the chaperonin containing TCP1 complex (CCT), also known as the TCP-1 Ring Complex (TRiC). CCT/TRiC is a molecular chaperone complex essential for the proper folding of many proteins within the cell.

CCT/TRiC is composed of eight different subunits (CCT1 to CCT8), with CCT2 being one of them. Each subunit is distinct but functionally interconnected, contributing to the complex's overall ability to assist in protein folding. CCT B/CCT2 plays a crucial role in this process, helping to ensure that newly synthesized proteins attain their correct three-dimensional conformations, which is vital for their functionality.The correct folding of proteins is fundamental to cell biology as misfolded proteins can lead to various diseases, including neurodegenerative disorders like Alzheimer's disease, and Huntington's disease. CCT B/CCT2, by virtue of its role in the CCT/TRiC complex, helps in preventing such misfolding events.CCT B/CCT2 is ubiquitously expressed in various tissues, highlighting its importance across a wide range of cellular functions. It is particularly crucial in the folding of actin and tubulin, proteins that are integral to the cell's cytoskeleton and play essential roles in cell structure, division, and intracellular transport.