BTNL10 Inhibitors

BTNL10, or Butyrophilin-like 10, is a transmembrane protein primarily expressed on the surface of antigen-presenting cells, including macrophages and dendritic cells. The protein is implicated in immune regulation and plays a crucial role in modulating T-cell responses. BTNL10's function is associated with the regulation of inflammatory processes and immune tolerance, making it a key player in maintaining immune homeostasis.

The general mechanisms of BTNL10 inhibition involve the modulation of intracellular signaling pathways crucial for immune responses. The identified inhibitors target pathways such as MAPK (Mitogen-Activated Protein Kinase), JAK-STAT (Janus Kinase-Signal Transducer and Activator of Transcription), and PI3K-AKT (Phosphoinositide 3-Kinase-Protein Kinase B). By disrupting these pathways, the inhibitors indirectly influence BTNL10 expression, impacting cellular processes related to inflammation, immune cell activation, and cytokine production. These intricate regulatory networks underscore the complex interplay between BTNL10 and key signaling cascades.