Date published: 2026-5-16

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BRP44 Activators

BRP44 activators belong to a distinctive chemical class characterized by their ability to modulate the activity of a specific protein known as BRP44 (Brain-specific receptor protein 44). These small molecules, also known as BRP44 agonists, exert their influence by binding to the BRP44 protein and triggering a cascade of intracellular events. BRP44 itself is primarily expressed in neural tissues, particularly within the brain, where it plays a pivotal role in various neurobiological processes. The activation of BRP44 by its dedicated class of compounds serves as a means to study and understand the intricate signaling pathways associated with neural function.

The mechanism of action of BRP44 activators typically involves a conformational change in the BRP44 protein upon binding, which, in turn, leads to downstream signaling events. These molecules are essential tools in the field of neuroscience research, as they enable scientists to manipulate and explore the functional consequences of BRP44 activation in a controlled manner. The insights gained from studying BRP44 activators can help unravel the intricate neural processes involved in synaptic plasticity, neuronal communication, and contribute to a deeper understanding of neurological disorders. As such, BRP44 activators are indispensable for researchers seeking to dissect the complex web of neural signaling pathways and their role in cognitive and behavioral processes.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

(±)-JQ1

1268524-69-1sc-472932
sc-472932A
5 mg
25 mg
$231.00
$863.00
1
(0)

JQ1 is a competitive inhibitor that binds to the bromodomain of BRP44, disrupting its interaction with acetylated histones and altering gene expression patterns.

GSK 525762A

1260907-17-2sc-490339
sc-490339A
sc-490339B
sc-490339C
sc-490339D
5 mg
10 mg
50 mg
100 mg
1 g
$300.00
$540.00
$940.00
$1680.00
$5900.00
(0)

I-BET762 is a BET inhibitor that hinders BRP44's binding to acetylated histones, resulting in reduced recruitment to chromatin and changes in gene transcription.

RVX 208

1044870-39-4sc-472700
10 mg
$340.00
(0)

RVX-208 selectively inhibits BET proteins, including BRP44, disrupting its interaction with acetylated histones and affecting gene expression.

PFI-1

1403764-72-6sc-478504
5 mg
$98.00
(0)

PFI-1 inhibits BRP44's binding to acetylated histones, indirectly activating BRP44 and influencing gene transcription patterns.

CPI-203

1446144-04-2sc-501599
1 mg
$170.00
(0)

CPI-203 paradoxically activates BRP44 by disrupting its binding to acetylated histones, altering its role in chromatin regulation.

4-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide

1395084-25-9sc-480120
5 mg
$300.00
(0)

MS436 is a synthetic BRP44 activator that enhances its interaction with acetylated histones, influencing gene transcription.